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. 2020 Jul 31;9(8):2461.
doi: 10.3390/jcm9082461.

Long-Term Evolution of Quality of Life and Symptoms Following Surgical Treatment for Endometriosis: Different Trajectories for Which Patients?

Aurélie Comptour  1   2 , Céline Lambert  3 , Pauline Chauvet  1   4 , Claire Figuier  1 , Anne-Sophie Gremeau  1 , Michel Canis  1   4 , Bruno Pereira  3 , Nicolas Bourdel  1   4
Affiliations

Long-Term Evolution of Quality of Life and Symptoms Following Surgical Treatment for Endometriosis: Different Trajectories for Which Patients?

Aurélie Comptour et al. J Clin Med. .

Abstract

Many studies have shown a global efficacy of laparoscopic surgery for patients with endometriosis in reducing painful symptoms and improving quality of life (QoL) in the short and long-term. The aim of this study was to analyze the different trajectories of long-term evolution in QoL and symptoms following surgical treatment for endometriosis, and to identify corresponding patient profiles. This prospective and multicenter cohort study concerned 962 patients who underwent laparoscopic treatment for endometriosis. QoL was evaluated using the Short Form (SF)-36 questionnaire and intensity of pain was reported using a visual analog scale prior to surgery and at 6, 12, 18, 24 and 36 months after surgery. Distinctive trajectories of pain and QoL evolution were identified using group-based trajectory modeling, an approach which gathers individuals into meaningful subgroups with statistically similar trajectories. Pelvic symptom trajectories (models of the evolution of dysmenorrhea, dyspareunia and chronic pelvic pain intensity over years) correspond to (1) patients with no pain or pain no longer after surgery, (2) patients with the biggest improvement in pain and (3) patients with continued severe pain after surgery. Our study reveals clear trajectories for the progression of symptoms and QoL after surgery that correspond to clusters of patients. This information may serve to complete information obtained from epidemiological methods currently used in selecting patients eligible for surgery.

Keywords: endometriosis; group-based trajectory modeling; pain; quality of life.

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Conflict of interest statement

The authors report no conflict of interest.

Figures

Figure 1
Figure 1
Trajectories of the long-term evolution of pelvic symptoms following surgical treatment for endometriosis. (A) Evolution of pelvic pain following surgical treatment; (B) Trajectories for each pelvic pain. For graph A, each curve represents mean ± standard error of the mean; ***: p < 0.001 compared to baseline. VAS: visual analog scale.
Figure 2
Figure 2
Trajectories of the long-term evolution of quality of life (PCS and MCS) following surgical treatment for endometriosis. For graphs (A) (PCS) and (B) (MCS), each curve represents mean ± standard error of the mean; ***: p < 0.001 compared to baseline. MCS: mental component summary; PCS: physical component summary.
Figure 3
Figure 3
Comparison of pelvic pain and quality-of-life trajectories. (A) PCS score; (B) MCS score. MCS: mental component summary; PCS: physical component summary.
Figure 4
Figure 4
Characteristics of each cluster of patients. Cpp: chronic pelvic pain; QoL: quality of life.
See this image and copyright information in PMC

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References

    1. Mabrouk M., Montanari G., Guerrini M., Villa G., Solfrini S., Vicenzi C., Mignemi G., Zannoni L., Frasca C., Di Donato N., et al. Does laparoscopic management of deep infiltrating endometriosis improve quality of life? A prospective study. Heal. Qual. Life Outcomes. 2011;9:98. doi: 10.1186/1477-7525-9-98. - DOI - PMC - PubMed
    1. Vercellini P., Aimi G., Busacca M., Apolone G., Uglietti A., Crosignani P.G. Laparoscopic uterosacral ligament resection for dysmenorrhea associated with endometriosis: Results of a randomized, controlled trial. Fertil. Steril. 2003;80:310–319. doi: 10.1016/S0015-0282(03)00613-7. - DOI - PubMed
    1. Ribeiro P.A., Sekula V.G., Abdalla-Ribeiro H.S., Rodrigues F.C., Aoki T., Aldrighi J.M. Impact of laparoscopic colorectal segment resection on quality of life in women with deep endometriosis: One year follow-up. Qual. Life Res. 2013;23:639–643. doi: 10.1007/s11136-013-0481-y. - DOI - PubMed
    1. Bassi M.A., Podgaec S., Dias J.A., Filho N.D., Petta C.A., Abrão M.S. Quality of Life after Segmental Resection of the Rectosigmoid by Laparoscopy in Patients with Deep Infiltrating Endometriosis with Bowel Involvement. J. Minim. Invasive Gynecol. 2011;18:730–733. doi: 10.1016/j.jmig.2011.07.014. - DOI - PubMed
    1. Parra R.S., Feitosa M.R., De Camargo H.P., Valério F.P., Zanardi J.V.C., Da Rocha J.J.R., Féres O. The impact of laparoscopic surgery on the symptoms and wellbeing of patients with deep infiltrating endometriosis and bowel involvement. J. Psychosom. Obstet. Gynecol. 2020:1–6. doi: 10.1080/0167482X.2020.1773785. - DOI - PubMed

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