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Review
. 2020 Sep 11;38(40):6199-6204.
doi: 10.1016/j.vaccine.2020.07.050. Epub 2020 Aug 1.

A review of the costs of delivering maternal immunisation during pregnancy

Simon R Procter  1 , Omar Salman  2 , Clint Pecenka  3 , Bronner P Gonçalves  4 , Proma Paul  5 , Raymond Hutubessy  6 , Philipp Lambach  7 , Joy E Lawn  8 , Mark Jit  9
Affiliations
Review

A review of the costs of delivering maternal immunisation during pregnancy

Simon R Procter et al. Vaccine. .

Abstract

Background: Routine maternal immunisation against influenza and pertussis are recommended by the WHO to protect mother and child, and new vaccines are under development. Introducing maternal vaccines into national programmes requires an understanding of vaccine delivery costs - particularly in low resource settings.

Methods: We searched Medline, Embase, Econlit, and Global Health for studies reporting costs of delivering vaccination during pregnancy but excluded studies that did not separate the vaccine purchase price. Extracted costs were inflated and converted to 2018 US dollars.

Results: Sixteen studies were included, of which two used primary data to estimate vaccine delivery costs. Costs per dose ranged from $0.55 to $0.64 in low-income countries, from $1.25 to $6.55 for middle-income countries, and from $5.76 to $39.87 in high-income countries.

Conclusions: More research is needed on the costs of delivering maternal immunisation during pregnancy, and of integrating vaccine delivery into existing programmes of antenatal care especially in low and middle-income countries.

Keywords: Costs; Economics; Immunisation; Maternal; Pregnancy; Vaccination.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flow diagram showing the screening process used to identify included studies.
See this image and copyright information in PMC

References

    1. Marchant A., Sadarangani M., Garand M., Dauby N., Verhasselt V., Pereira L. Maternal immunisation: collaborating with mother nature. Lancet Infect Dis. 2017;17(7):e197–e208. - PubMed
    1. World Health Organisation. WHO | Neonatal mortality [Internet]. [cited 2020 Feb 21]. Available from: https://www.who.int/gho/child_health/mortality/neonatal/en/.
    1. Omer S.B. Maternal Immunization. Longo DL, editor. N Engl J Med. 2017;376(13):1256–1267. - PubMed
    1. World Health Organisation Vaccines against influenza WHO position paper – November 2012. Wkly Epidemiol Rec. 2012;87(47):461–476. - PubMed
    1. Zaman K., Roy E., Arifeen S.E., Rahman M., Raqib R., Wilson E. Effectiveness of Maternal Influenza Immunization in Mothers and Infants. N Engl J Med. 2008;359(15):1555–1564. - PubMed

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