Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul 10:11:1054.
doi: 10.3389/fphar.2020.01054. eCollection 2020.

Efficacy, Chemical Constituents, and Pharmacological Actions of Radix Paeoniae Rubra and Radix Paeoniae Alba

Yu-Qing Tan  1   2 , Heng-Wen Chen  1 , Jun Li  1 , Qing-Juan Wu  1
Affiliations
Review

Efficacy, Chemical Constituents, and Pharmacological Actions of Radix Paeoniae Rubra and Radix Paeoniae Alba

Yu-Qing Tan et al. Front Pharmacol. .

Abstract

Radix Paeoniae Rubra and Radix Paeoniae Alba are the different characteristic forms of Paeonia lactiflora Pall. They are widely used as traditional Chinese medicines in clinical practices. This study analyzes the development history, efficacy, chemical compositions, and pharmacological effects of Radix Paeoniae Rubra and Radix Paeoniae Alba, and explores the causes of the similarities and differences of these two amalgams. It provides a basis for the clinical application of these two Chinese medicinal materials, and lays a foundation for further study of the pharmacological effects and the quality identification of Paeonia lactiflora Pall as it applies to traditional Chinese medicine.

Keywords: Radix Paeoniae Alba; Radix Paeoniae Rubra; chemical constituents; efficacy; pharmacological actions.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) Characteristics of RPR. (B) Characteristics of RPA.
Figure 2
Figure 2
Main chemical compositions of RPR and RPA. Radix Paeoniae Rubra (RPR), Radix Paeoniae Alba (RPA).
Figure 3
Figure 3
Chemical structures of paeoniflorin and albiflorin.
Figure 4
Figure 4
The hepatoprotective effect of RPR by inhibition of inflammatory reactions or resistance to oxidative damage.
Figure 5
Figure 5
The therapeutic effect of RPR on cardiovascular disease.
Figure 6
Figure 6
Regulation of the MAPK and NF-κB signaling pathways by RPA.
Figure 7
Figure 7
Regulation of the immune system by TGP.
See this image and copyright information in PMC

References

    1. Cai Y. M., Cui X. F., Liu Y. Y. (1997). A summary of materia medica of south yunnan. J. Med. Pharm. Chin. Minor. S1, 90–91. 10.16041/j.cnki.cn15-1175.1997.s1.093 - DOI
    1. Chen C., Du P., Wang J. (2015). Paeoniflorin ameliorates acute myocardial infarction of rats by inhibiting inflammation and inducible nitric oxide synthase signaling pathways. Mol. Med. Rep. 12, 3937–3943. 10.3892/mmr.2015.3870 - DOI - PubMed
    1. Chen Y., Wang Y., Xu L., Zhu W., Xu C., Xu M., et al. (2019). Influence of total glucosides of paeony on PD-1/PD-L1 expression in primary Sjogren’s syndrome. Int. J. Rheumatol. Dis. 22, 200–206. 10.1111/1756-185X.13391 - DOI - PubMed
    1. Chinese Pharmacopoeia Commission (2015). Pharmacopoeia of the People’s Republic of China Vol. 105 (Beijing: China Medical Science and Technology Press; ), 158.
    1. Gao S. H., Hu Z. T., Dong L. Y. (2012). Protective effect and mechanism of total paeony glycoside on radiactived hepatic fibrosis in rats. Pharm. Clin. Chin. Mater. Med. 28, 66–69. 10.13412/j.cnki.zyyl.2012.02.029 - DOI