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. 1977 Jul 15;197(4300):279-82.
doi: 10.1126/science.327547.

Macrophage tumor killing: influence of the local environment

J B Hibbs Jr, R R Taintor, H A Chapman Jr, J B Weinberg

Macrophage tumor killing: influence of the local environment

J B Hibbs Jr et al. Science. .

Abstract

Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.

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