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Review
. 1988 Jan 1;61(1):36-45.
doi: 10.1002/1097-0142(19880101)61:1<36::aid-cncr2820610108>3.0.co;2-6.

5-Fluorouracil-associated cardiotoxicity

N J Freeman  1 , M E Costanza
Affiliations
Review

5-Fluorouracil-associated cardiotoxicity

N J Freeman et al. Cancer. .

Abstract

Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.

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