Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Sep;215(3):770-780.
doi: 10.2214/AJR.20.22837. Epub 2020 Jul 1.

A Review of the Mechanisms and Clinical Implications of Precision Cancer Therapy-Related Toxicity: A Primer for the Radiologist

Richard Thomas  1   2 , Stephanie A Howard  1   2 , Shawn L Laferriere  1   2   3 , Marta Braschi-Amirfarzan  1   2   4
Affiliations
Review

A Review of the Mechanisms and Clinical Implications of Precision Cancer Therapy-Related Toxicity: A Primer for the Radiologist

Richard Thomas et al. AJR Am J Roentgenol. 2020 Sep.

Abstract

OBJECTIVE. The purpose of this review is to elucidate the mechanisms, types, and clinical significance of molecular targeted therapy (MTT) and immune checkpoint inhibitors (ICIs) and their related toxicity, emphasizing the radiologic manifestations. CONCLUSION. The related toxicities of MTT and ICIs can have acute, recurrent, chronic, and delayed presentations. These toxicities may serve as markers of response and survival. By understanding the clinical significance of drug toxicities, radiologists can play an important role in personalized cancer therapy.

Keywords: adverse effect; cancer; imaging; immune checkpoint inhibitor; molecular targeted therapy; oncology; toxicity.

PubMed Disclaimer

MeSH terms

LinkOut - more resources