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Comment
. 2020 Aug 4;32(2):152-153.
doi: 10.1016/j.cmet.2020.07.011.

The Link between Stress and IL-6 Is Heating Up

Justin Darcy  1 , Yu-Hua Tseng  2
Affiliations
Comment

The Link between Stress and IL-6 Is Heating Up

Justin Darcy et al. Cell Metab. .

Abstract

Psychological stress has long been known to reduce adaptability to inflammatory challenges, although the precise mechanism has remained elusive. In a recent issue of Cell, Qing et al. (2020) demonstrate that psychological stress induces secretion of IL-6 from brown adipose tissue, which promotes hepatic gluconeogenesis, and reduces host fitness to inflammatory insults.

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Figures

Figure 1.
Figure 1.. Brown fat secretion of IL-6: It depends on the stimulus.
A. Qing et al. demonstrated that in murine models, psychological stress induces brown fat to release IL-6, which increases hepatic gluconeogenesis. Unfortunately, this results in impaired host tolerance to inflammatory challenges. B. Normal activation of brown adipose tissue through cold exposure causes the release of BATokines that influence metabolism; however, it does not induce the release of IL-6.
See this image and copyright information in PMC

Comment on

  • Origin and Function of Stress-Induced IL-6 in Murine Models.
    Qing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Qing H, et al. Cell. 2020 Jul 23;182(2):372-387.e14. doi: 10.1016/j.cell.2020.05.054. Epub 2020 Jun 30. Cell. 2020. PMID: 32610084 Free PMC article.

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