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Review
. 2020 Sep-Oct;14(5):1361-1376.
doi: 10.1016/j.dsx.2020.07.022. Epub 2020 Jul 21.

Vaccine development against coronavirus (2003 to present): An overview, recent advances, current scenario, opportunities and challenges

Kirtikumar C Badgujar  1 , Vivek C Badgujar  2 , Shamkant B Badgujar  3
Affiliations
Review

Vaccine development against coronavirus (2003 to present): An overview, recent advances, current scenario, opportunities and challenges

Kirtikumar C Badgujar et al. Diabetes Metab Syndr. 2020 Sep-Oct.

Abstract

Background and aim: The pandemic COVID-19 occurring due to novel emerging coronavirus-2019 (SARS-CoV-2) is severely affecting the worldwide public health, culture, economy and human social behaviour. Till date, there is no approved medicine/treatment to cure COVID-19, whereas, vaccine development efforts are going on high priority. This review aimed to provide an overview of prior art, recent advances, vaccine designing strategies, current scenario, opportunities and challenges related to development of coronavirus vaccine.

Method: A literature survey was conducted using Scopus, PubMed and Google Scholar with the search key as: coronavirus vaccine, SARS vaccine, MERS vaccine and COVID-19 vaccine. Articles related to above search query were retrieved, sorted, analyzed and developed into an easy-to-understand review.

Results: The genome phylogenetic analysis suggested that genomic sequence of SARS-CoV-2 is almost 80% similar to that of SARS-CoV, further both these viruses bind to same host cell receptor ACE-2. Hence it is expected that, previously available literature data about coronavirus vaccine designing may play crucial role in development of rapid vaccine against COVID-19. In view of this, the present review discuss (i) existing information (from 2003 to present) about the type of vaccine, antigen, immunogenic response, animal model, route of administration, adjuvants and current scenario for designing of coronavirus vaccine (ii) potential factors and challenges related to rapid development of COVID-19 vaccine.

Conclusion: In conclusion, we discuss possible clues/ target sites for designing of vaccine against SARS-CoV-2 virus based on prior-art.

Keywords: Adjuvants; Antigens; COVID-19 vaccine; Coronavirus disease vaccine; Spike protein.

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Conflict of interest statement

Declaration of competing interest On the behalf of all authors, I corresponding author confirms that there is no conflicts of interest.

Figures

Fig. 1
Fig. 1
Scopus related literature survey regarding to vaccine development against coronavirus (by date May 29, 2020).
See this image and copyright information in PMC

References

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