Alzheimer's disease disrupts domain-specific and domain-general processes in numerosity estimation

Abstract

Introduction: This study investigated how Alzheimer's Disease (AD) affects numerosity estimation abilities (e.g., finding the approximate number of items in a collection).

Method: Across two experiments, performance from HOA (i.e., Healthy Older Adults; N = 48) and AD patients (N = 50) was compared on dot comparison tasks. Participants were presented with two dot arrays and had to select the more numerous dot array in comparison tasks. They also took a Simon task and a number-line tasks (i.e., number-line tasks in which they had to indicate the position of a number on a line 0 to 100 or on a line 0 to 1,000 in the number-line task).

Results: In Experiment 1, (a) AD patients obtained significantly poorer performance while comparing collections of dots, especially harder (small-ratio) collections, (b) these deficits correlated with poorer performance on the number-line task for larger numerosities (i.e., 0 to 1,000), and (c) AD patients showed poorer performance on incongruent (where numerosity and area occupied by dots mismatched) than on congruent items (where both features matched), while HOA showed no congruency effects. Experiment 2 showed (a) congruency effects in both groups when convex hull was tested as an incongruent feature, and (b) comparable sequential modulations of congruency effects in both groups.

Conclusions: Our findings showed that numerosity abilities decline in AD patients, and that this decline results from impaired domain-specific processes (i.e., numerosity processing) and domain-general processes (i.e., inhibition). These findings have important implications to further our understanding of how specific and general cognitive processes contribute to numerosity estimation/comparison performance, and how such contributions change during Alzheimer's disease.

Keywords: Alzheimer’s disease; dot comparison; executive control; inhibition; numerosity processing.