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. 2020 Oct 1;202(7):1037-1039.
doi: 10.1164/rccm.202006-2219LE.

Pulmonary Vascular Dilatation Detected by Automated Transcranial Doppler in COVID-19 Pneumonia

Alexandra S Reynolds  1 , Alison G Lee  1 , Joshua Renz  2 , Katherine DeSantis  2 , John Liang  1 , Charles A Powell  1 , Corey E Ventetuolo  3 , Hooman D Poor  1
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Pulmonary Vascular Dilatation Detected by Automated Transcranial Doppler in COVID-19 Pneumonia

Alexandra S Reynolds et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Assessment of microbubbles by transcranial Doppler (TCD) after injection of agitated saline. Representative images were captured during TCD evaluation after injection of agitated saline. (A and B) Continuous spectral waveforms of the middle cerebral artery (MCA) during insonation over 5 seconds. C and D demonstrate the power M-mode, and positive microbubbles appear as vertical lines (arrows). (A and C) Images from the left MCA of a 60-year-old woman in whom TCD detected five microbubbles. (B and D) Images from the right MCA of a 69-year-old man in whom TCD detected 300 microbubbles. His PaO2:FiO2 ratio was 55 mm Hg, which was the lowest in the cohort.
Figure 2.
Figure 2.
Associations between number of microbubbles and PaO2:FiO2 ratio and lung compliance. (A) A scatterplot of the log-transformed number of microbubbles as detected by transcranial Doppler and PaO2:FiO2 ratio (r = −0.55; P = 0.02) and suggests that the number of microbubbles increases with declining PaO2:FiO2 ratio. (B) A scatterplot of the log-transformed number of microbubbles as detected by transcranial Doppler and lung compliance (r = −0.61; P = 0.01) and suggests that the number of microbubbles increases with declining lung compliance.
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