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Comment
. 2020 Oct 1;26(19):5059-5061.
doi: 10.1158/1078-0432.CCR-20-2321. Epub 2020 Aug 5.

Quest for Ideal Composite Biomarkers for Response to Immunotherapies

Umang Swami  1 , Roberto H Nussenzveig  1 , Neeraj Agarwal  2
Affiliations
Comment

Quest for Ideal Composite Biomarkers for Response to Immunotherapies

Umang Swami et al. Clin Cancer Res. .

Abstract

In the CheckMate 275 study, composite biomarkers appear to better predict response to immunotherapy over individual ones. Nevertheless, the path forward needs consensus guidelines for biomarker interpretation. Thereafter, prospective validation with real-time, serial biospecimen collection along with the development of composite biomarker models leads to the goal of personalized therapy.See related article by Galsky et al., p. 5120.

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