Lung Screen Uptake Trial: results from a single lung cancer screening round

Mamta Ruparel¹, Samantha L Quaife², Jennifer L Dickson¹, Carolyn Horst¹, Sophie Tisi¹, Helen Hall¹, Magali Taylor³, Asia Ahmed³, Penny Shaw³, Stephen Burke⁴, May-Jan Soo⁴, Arjun Nair³, Anand Devaraj⁵, Karen Sennett⁶, Stephen W Duffy⁷, Neal Navani^{1

8}, Angshu Bhowmik⁹, David R Baldwin¹⁰, Sam M Janes¹¹

Affiliations

¹ Lungs for Living Research Centre, UCL Respiratory, University College London, London, England, UK.
² Research Department of Behavioural Science and Health, University College London, London, UK.
³ Department of Radiology, University College London Hospitals NHS Foundation Trust, London, London, UK.
⁴ Department of Radiology, Homerton University Hospital NHS Foundation Trust, London, London, UK.
⁵ Department of Radiology, Royal Brompton Hospital, London, UK.
⁶ Killick Street Health Centre, London, UK.
⁷ Wolfson Institute of Preventive Medicine, Barts and London, London, UK.
⁸ Thoracic Medicine Department, University College London Hospitals NHS Foundation Trust, London, London, UK.
⁹ Respiratory Medicine, Homerton University Hospital NHS Foundation Trust, London, London, UK.
¹⁰ Respiratory Medicine Unit, David Evans Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, UK.
¹¹ Lungs for Living Research Centre, UCL Respiratory, University College London, London, England, UK s.janes@ucl.ac.uk.

PMID: 32759387
PMCID: PMC7509385
DOI: 10.1136/thoraxjnl-2020-214703

Observational Study

Lung Screen Uptake Trial: results from a single lung cancer screening round

Mamta Ruparel et al. Thorax. 2020 Oct.

. 2020 Oct;75(10):908-912.

doi: 10.1136/thoraxjnl-2020-214703. Epub 2020 Aug 5.

Authors

Affiliations

¹ Lungs for Living Research Centre, UCL Respiratory, University College London, London, England, UK.
² Research Department of Behavioural Science and Health, University College London, London, UK.
³ Department of Radiology, University College London Hospitals NHS Foundation Trust, London, London, UK.
⁴ Department of Radiology, Homerton University Hospital NHS Foundation Trust, London, London, UK.
⁵ Department of Radiology, Royal Brompton Hospital, London, UK.
⁶ Killick Street Health Centre, London, UK.
⁷ Wolfson Institute of Preventive Medicine, Barts and London, London, UK.
⁸ Thoracic Medicine Department, University College London Hospitals NHS Foundation Trust, London, London, UK.
⁹ Respiratory Medicine, Homerton University Hospital NHS Foundation Trust, London, London, UK.
¹⁰ Respiratory Medicine Unit, David Evans Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, UK.
¹¹ Lungs for Living Research Centre, UCL Respiratory, University College London, London, England, UK s.janes@ucl.ac.uk.

PMID: 32759387
PMCID: PMC7509385
DOI: 10.1136/thoraxjnl-2020-214703

Abstract

The Lung Screen Uptake Trial tested a novel invitation strategy to improve uptake and reduce socioeconomic and smoking-related inequalities in lung cancer screening (LCS) participation. It provides one of the first UK-based 'real-world' LCS cohorts. Of 2012 invited, 1058 (52.6%) attended a 'lung health check'. 768/996 (77.1%) in the present analysis underwent a low-dose CT scan. 92 (11.9%) and 33 (4.3%) participants had indeterminate pulmonary nodules requiring 3-month and 12-month surveillance, respectively; 36 lung cancers (4.7%) were diagnosed (median follow-up: 1044 days). 72.2% of lung cancers were stage I/II and 79.4% of non-small cell lung cancer had curative-intent treatment.

Keywords: imaging/CT MRI etc; lung cancer.

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Conflict of interest statement

Competing interests: SMJ, MR, JLD, CH, ST and HH are supported by funding for a large trial of low dose CT screening, called the ‘SUMMIT Study’ by GRAIL Inc. SLQ and NN collaborate on the SUMMIT Study. SMJ has received honoraria from AstraZeneca, BARD1 Bioscience and Janssen for being an Advisory Board Expert and travel to a US conference. SMJ received grant funding from Owlstone for a separate research study and has a family member who has a financial association with AstraZeneca. MR has received travel funding for a conference from Takeda and an honorarium for planning and speaking at educational meetings from AstraZeneca.

Figures

**Figure 1**
Flow chart of invitees and participants demonstrating numbers identified, invited, enrolled, eligible for LDCT and that completed a LDCT examination. DNA, did not attend; LDCT, low-dose CT; LLP, Liverpool Lung Project; MDT, multidisciplinary team; PLCO_m2012, Prostate, Lung, Colorectal and Ovarianstudy model 2012; USPSFT, United States Preventive Services Task Force.

See this image and copyright information in PMC

References

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1. de Koning HJ, van der Aalst CM, de Jong PA, et al. . Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med 2020;382:503–13. 10.1056/NEJMoa1911793 - DOI - PubMed
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Lung Screen Uptake Trial: results from a single lung cancer screening round

Affiliations

Lung Screen Uptake Trial: results from a single lung cancer screening round

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical