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Review
. 2020 Jul 15:11:774.
doi: 10.3389/fphys.2020.00774. eCollection 2020.

Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1

Minxuan Liu  1 , Gina Galli  2 , Yilin Wang  3 , Qiru Fan  1   4 , Zhenzhong Wang  1 , Xin Wang  2 , Wei Xiao  1
Affiliations
Review

Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1

Minxuan Liu et al. Front Physiol. .

Abstract

Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosphorylation. Hypoxia-inducible factor (HIF) is activated in hypoxic conditions and acts as an important modulator of diverse target genes in the human body. The downstream genes of HIF include vital modulators of cardiovascular-related signaling pathways. Therefore, it is hypothesized that HIF represents a potential therapeutic target for the treatment and prevention of cardiovascular diseases. In this short review, we introduce the pathophysiology of hypoxic injury in cardiovascular disease, and we conclude from convincing evidence that HIF can modulate relevant cardioprotective signaling pathways.

Keywords: HIF; atherosclerosis; cardiovascular disease; hypoxia; myocardial infarction; therapeutic target.

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Figures

FIGURE 1
FIGURE 1
HIF-1α signaling.
See this image and copyright information in PMC

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