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Review
. 2020 Jul 3;7(7):ofaa276.
doi: 10.1093/ofid/ofaa276. eCollection 2020 Jul.

Drugs for Gram-Negative Bugs From 2010-2019: A Decade in Review

Benjamin A Pontefract  1 , Hong T Ho  1 , Alexandria Crain  1 , Madan K Kharel  2 , S Eric Nybo  1
Affiliations
Review

Drugs for Gram-Negative Bugs From 2010-2019: A Decade in Review

Benjamin A Pontefract et al. Open Forum Infect Dis. .

Abstract

A literature review spanning January 1, 2010, to December 31, 2019, was conducted using the PubMed and ISI Web of Science databases to determine the breadth of publication activity in the area of gram-negative bacteria antimicrobial therapy. The number of articles was used as a reflection of scholarly activity. First, PubMed was searched using the following Medical Subject Headings (MeSH): antibacterial agents, Enterobacteriaceae, Acinetobacter, and Pseudomonas. A total of 12 643 articles were identified within PubMed, and 77 862 articles were identified within ISI Web of Science that included these terms. Second, these articles were categorized by antibiotic class to identify relative contributions to the literature by drug category. Third, these studies were used to identify key trends in the treatment of gram-negative bacterial infections from the past decade. This review highlights advances made in the past 10 years in antibacterial pharmacotherapy and some of the challenges that await the next decade of practice.

Keywords: Acinetobacter; Enterobacteriaceae; Pseudomonas; antibacterial pharmacotherapy; gram-negative bacteria.

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Figures

Figure 1.
Figure 1.
Literature search strategy and results. Abbreviation: MeSH, Medical Subject Headings.
Figure 2.
Figure 2.
Total number of publications about gram-negative antimicrobials published from 2010 to 2019. A, The total number of publications indexed in PubMed. B, The total number of publications indexed in ISI Web of Science.
Figure 3.
Figure 3.
Citation analysis of publications from 2010–2019 from a Web of Science literature search. A, Total citation count and the number of citing articles and (B) Average h-index and average citations per item.
Figure 4.
Figure 4.
Percent contribution of total publications per drug class from 2010–2019.
See this image and copyright information in PMC

References

    1. Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N Engl J Med 2010; 362:1804–13. - PMC - PubMed
    1. Miller SI. Antibiotic resistance and regulation of the gram-negative bacterial outer membrane barrier by host innate immune molecules. mBio 2016; 7:e01541-16. - PMC - PubMed
    1. Vaidya VK. Horizontal transfer of antimicrobial resistance by extended-spectrum β lactamase-producing Enterobacteriaceae. J Lab Physicians 2011; 3:37–42. - PMC - PubMed
    1. Gomez JE, Kaufmann-Malaga BB, Wivagg CN, et al. . Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. 2017; 6:e20420. - PMC - PubMed
    1. Nikaido H. Multidrug efflux pumps of gram-negative bacteria. J Bacteriol 1996; 178:5853–9. - PMC - PubMed