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Meta-Analysis
. 2021 Apr;45(4):821-835.
doi: 10.1007/s00264-020-04660-4. Epub 2020 Aug 6.

Is coating of titanium implants effective at preventing Staphylococcus aureus infections? A meta-analysis of animal model studies

Konstantinos Tsikopoulos  1 , Konstantinos Sidiropoulos  2 , Dimitrios Kitridis  3 , Anas Hassan  4 , Lorenzo Drago  5 , Andreas Mavrogenis  6 , Donald McBride  7
Affiliations
Meta-Analysis

Is coating of titanium implants effective at preventing Staphylococcus aureus infections? A meta-analysis of animal model studies

Konstantinos Tsikopoulos et al. Int Orthop. 2021 Apr.

Abstract

Aim of the study: To assess the effects of the available coating methods against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) biofilm development on titanium implants.

Methods: We searched the MEDLINE, Embase, and CENTRAL databases until May 18, 2019, for studies that used animal models of infections to evaluate various titanium implant coating methods to prevent S. aureus infection. Twenty-seven studies were eligible for inclusion in qualitative synthesis. Of those, twenty-three were considered in pair-wise meta-analysis. In addition, subgroup analysis of implant protection strategies relative to uncoated controls was performed, and any adverse events stemming from the coating applications were reported. Quality assessment was performed using SYRCLE's risk of bias tool for animal studies.

Results: Meta-analysis showed that active coating with antibiotics was favoured over uncoated controls (standardised mean differences [SMD] for MRSA and MSSA were - 2.71 [95% CI, - 4.24 to - 1.18], p = 0.0005, and - 2.5 [- 3.79 to - 1.22], p = 0.0001, respectively). Likewise, large effect sizes were demonstrated when a combination of active and conventional non-degradable passive coatings was compared with controls (SMDs for MRSA and MSSA were - 0.62 [95% CI, - 1.15 to - 0.08], p = 0.02, and - 1.93 [95% CI, - 2.87 to - 0.98], p < 0.001, respectively).

Discussion/conclusion: As a standalone prevention method, active titanium coating with antibiotics yielded promising results against both MSSA and MRSA. Combinations between active and non-degradable passive coatings, potentially allowing for sustained antimicrobial substance release, provided consistent hardware infection protection. Thus, we recommend that future research efforts focus on combined coating modalities against S. aureus biofilm infections in the presence of titanium implants.

Systematic review registration: CRD42019123462.

Keywords: Biofilm; Coating; Infection prevention; Prophylaxis; Staphylococcus; Titanium.

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