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Randomized Controlled Trial
. 2020 Nov;43(11):1273-1278.
doi: 10.1002/clc.23439. Epub 2020 Aug 6.

Effects of resistance exercise on treatment outcome and laboratory parameters of Takayasu arteritis with magnetic resonance imaging diagnosis: A randomized parallel controlled clinical trial

Guoce Li  1 , Fenghai Liu  1 , Yan Wang  2 , Meng Zhao  1 , Yancheng Song  1 , Lei Zhang  1
Affiliations
Randomized Controlled Trial

Effects of resistance exercise on treatment outcome and laboratory parameters of Takayasu arteritis with magnetic resonance imaging diagnosis: A randomized parallel controlled clinical trial

Guoce Li et al. Clin Cardiol. 2020 Nov.

Abstract

Background: Elevated tumor necrosis factor-α (TNF-α) is correlated with refractory Takayasu arteritis (TA), and resistance exercise have been shown to inhibit TNF-α.

Hypothesis: We aimed to explore the effect of resistance exercise in the clinical management of TA.

Methods: This clinical trial enrolled a total of 342 acute TA patients, who were subsequently randomized to undergo either resistance exercise or relaxation control twice per week for 12 weeks. The disease activity was defined using the primary outcome of Birmingham Vascular Activity Score (BVAS). Secondary outcomes included levels of plasma TNF-α and C-reactive protein (CRP), and the erythrocyte sedimentation rate (ESR).

Results: BVAS scores along with other laboratory parameters obtained from the patients in the resistance exercise group showed a gradual decline throughout the course of the trial. By contrast, outcomes appeared largely unaltered in the relaxation control group patients. Analyses also revealed that plasma TNF-α displayed strong linear correlations with ESR, BVAS scores, and plasma CRP levels.

Conclusion: Resistance exercise could substantially improve treatment outcomes as well as laboratory parameters in patients with acute TA, probably through decreasing TNF-α.

Keywords: Birmingham vascular activity score; C-reactive protein; MRI; Takayasu arteritis; resistance exercise.

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Conflict of interest statement

The authors declare no potential conflict of interests.

Figures

FIGURE 1
FIGURE 1
Study design illustration
FIGURE 2
FIGURE 2
Birmingham Vascular Activity Score scores of eligible patients from the two groups. Data are shown in mean ± SD, **P < .01, *P < .05, ns not significant, resistance exercise group vs relaxation control group at indicated follow‐up time points
FIGURE 3
FIGURE 3
A, Erythrocyte sedimentation rate; B, plasma levels of C‐reactive protein; and C, tumor necrosis factor‐α of eligible patients from the two groups. Data are shown in mean ± SD, **P < .01, *P < .05, ns not significant, resistance exercise group vs relaxation control group at indicated follow‐up time points
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