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. 2021 May;23(5):504-511.
doi: 10.1080/10286020.2020.1794857. Epub 2020 Aug 7.

Fusapyrone A, a γ-pyrone derived from a desert Fusarium sp

Xin Zhen  1 , Meng-Jia Mao  1   2 , Ren-Zhong Wang  1 , Shan-Shan Chang  1 , Tong-Mei Xiao  1 , Ye-Xiang Wu  1 , Li-Yan Yu  1 , Ya-Li Song  2 , Ming-Hua Chen  1   3 , Shu-Yi Si  1
Affiliations

Fusapyrone A, a γ-pyrone derived from a desert Fusarium sp

Xin Zhen et al. J Asian Nat Prod Res. 2021 May.

Abstract

In this work, we isolated and characterized fusapyrone A (1), a new γ-pyrone derivative, along with six previously described compounds from the rice fermentation of Fusarium sp. CPCC 401218, a fungus collected from the desert. The structure of 1 was characterized using various spectroscopic analyses, such as MS, IR, 1D, and 2D NMR. The absolute configuration of 1 was determined through the use of 13C NMR chemical shifts, electronic circular dichroism (ECD) and optical rotation (OR) calculations. Compound 1 was found to have weak antiproliferative activity for Hela cells, with an IC50 of 50.6 μM.[Formula: see text].

Keywords: ECD calculation; Fusarium sp; OR calculation; cytotoxicity; γ-pyrone.

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