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. 2022 Feb;36(3):754-759.
doi: 10.1080/14786419.2020.1802268. Epub 2020 Aug 7.

Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases

Qian-Qian Zhao  1   2 , Wen-Jun Wei  1 , Ya Li  1 , Kun Gao  1
Affiliations

Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases

Qian-Qian Zhao et al. Nat Prod Res. 2022 Feb.

Abstract

Three new highly modified lanostane triterpenoids schisanchinlactone A-C (1-3), together with six known compounds (4-9) were isolated from the stems and leaves of Schisandra chinensis. Their structures were established by extensive spectroscopic analyses. Compounds 7 and 8 showed significant inhibition of Cdc25A phosphatase with inhibitory rates of 85.5% and 98.1%, respectively, at the concentration of 100 μM.

Keywords: Cdc25A/B phosphatases; Schisandra chinensis; lignan; triterpenoid.

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