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. 2020 Aug 6;182(3):537-539.
doi: 10.1016/j.cell.2020.07.014.

Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor

Claudio J Villanueva  1
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Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor

Claudio J Villanueva. Cell. .
Free article

Abstract

Oguri and colleagues use single-cell RNA sequencing to identify a beige adipocyte precursor cell that gives rise to thermogenic adipocytes in subcutaneous adipose tissue. These beige fat progenitors are marked by PDGFRα, Sca1, and CD81 and proliferate upon activation of FAK-signaling in response to the cold and irisin.

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  • CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
    Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. Oguri Y, et al. Cell. 2020 Aug 6;182(3):563-577.e20. doi: 10.1016/j.cell.2020.06.021. Epub 2020 Jul 1. Cell. 2020. PMID: 32615086 Free PMC article.

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