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Comment
. 2020 Aug 6;79(3):368-370.
doi: 10.1016/j.molcel.2020.07.014.

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R Savani  1 , Kalil G Abdullah  2 , Samuel K McBrayer  3
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Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R Savani et al. Mol Cell. .
Free article

Abstract

A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

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