Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov:85:104494.
doi: 10.1016/j.meegid.2020.104494. Epub 2020 Aug 5.

A systematic review of re-detectable positive virus nucleic acid among COVID-19 patients in recovery phase

Zhiru Gao  1 , Yinghui Xu  1 , Ye Guo  1 , Dongsheng Xu  1 , Li Zhang  2 , Xu Wang  1 , Chao Sun  1 , Shi Qiu  1 , Kewei Ma  3
Affiliations

A systematic review of re-detectable positive virus nucleic acid among COVID-19 patients in recovery phase

Zhiru Gao et al. Infect Genet Evol. 2020 Nov.

Abstract

A large number of coronavirus disease 2019 (COVID-19) patients have been cured and discharged due to timely and effective treatments. While some discharged patients have been found re-positive nucleic acid again in the recovery phase. Until now, there is still a great challenge to its infectivity and the specific potential mechanism which needs further discussion. However, more intensive attention should be paid to the prognosis of recovered patients. In this review, we mainly focus on the characteristics, potential reasons, infectivity, and outcomes of re-detectable positive patients, thereby providing some novel insights into the cognition of COVID-19.

Keywords: COVID-19; Characteristic; Outcome; Recovered patients; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

The authors declared that they have no conflict of interests.

References

    1. An J., et al. Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test. medRxiv. 2020 doi: 10.1101/2020.03.26.20044222. - DOI - PMC - PubMed
    1. Balachandar V., et al. Follow-up studies in COVID-19 recovered patients - is it mandatory? Sci. Total Environ. 2020;729:139021. - PMC - PubMed
    1. Bentivegna E., et al. New IgM seroconversion and positive RT-PCR test after exposure to the virus in recovered COVID-19 patient. J. Med. Virol. 2020 doi: 10.1002/jmv.26160. - DOI - PMC - PubMed
    1. Bongiovanni M., Basile F. Re-infection by COVID-19: a real threat for the future management of pandemia? Infect. Dis. (Lond.) 2020;52:581–582. - PubMed
    1. Chen D., et al. Recurrence of positive SARS-CoV-2 RNA in COVID-19: A case report. Int. J. Infect. Dis. 2020;93:297–299. - PMC - PubMed

Publication types