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. 2020 Aug 5;56(8):390.
doi: 10.3390/medicina56080390.

The Relationship between Selected Demographic Factors and Speech Organ Dysfunction in Sporadic ALS Patients

Wioletta Pawlukowska  1   2 , Bartłomiej Baumert  3 , Monika Gołąb-Janowska  2 , Agnieszka Meller  2 , Karolina Machowska-Sempruch  2 , Agnieszka Wełnicka  2 , Edyta Paczkowska  3 , Iwona Rotter  1 , Bogusław Machaliński  3 , Przemysław Nowacki  2
Affiliations

The Relationship between Selected Demographic Factors and Speech Organ Dysfunction in Sporadic ALS Patients

Wioletta Pawlukowska et al. Medicina (Kaunas). .

Abstract

Background and objectives: Speech disorders are observed in 30% of newly diagnosed sporadic amyotrophic lateral sclerosis (ALS) patients. Characterized by a dynamic course, dysfunction of articulation has not so far been well understood. The aim of this study was to analyze the influence of demographic factors (sex, age, duration of the disease) and concomitant diseases (degenerative spine disease, depression, hypertension, hypothyroidism, hyperthyroidism, and allergy) on the functioning of speech organs in ALS patients. Materials and Methods: The study group consisted of 65 patients with sporadic ALS. Patients were examined for articulatory functions by means of the Frenchay Dysarthria Assessment (FDA). Results: 68% of the study sample had spinal disorders. Logistic regression analysis showed that a decline in the functioning of lips, soft palate, length of phonation, and voice loudness was more common among men. Patients diagnosed with degenerative spine disease more often suffered from respiratory disorders, while younger patients (<60 years of age) significantly more often had the impairment of the sentence and spontaneous speech functions. Conclusions: The male gender in patients with ALS is associated with an increased risk of deterioration of the phonation length function. Patients under 60 years of age are associated with more often pronouncing sentences disorders and spontaneous speech disorders.

Keywords: Frenchay dysarthria assessment; amyotrophic lateral sclerosis; dysarthria; speech disorders.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. van Es M.A., Hardiman O., Chio A., Al-Chalabi A., Pasterkamp R.J., Veldink J.H., van den Berg L.H. Amyotrophic lateral sclerosis. Lancet. 2017;4:2084–2098. doi: 10.1016/S0140-6736(17)31287-4. - DOI - PubMed
    1. Sutedja N.A., Veldink J.H., Fischer K., Kromhout H., Wokke J.H., Huisman M.H., Heederik D.J., Van den Berg L.H. Lifetime occupation education, smoking, and risk of ALS. Neurology. 2007;69:1508–1514. doi: 10.1212/01.wnl.0000277463.87361.8c. - DOI - PubMed
    1. Murphy N.A., Arthur K.C., Tienari P.J., Houlden H., Chiò A., Traynor B.J. Age-related penetrance of the C9orf72 repeat expansion. Sci. Rep. 2017;7:2116. doi: 10.1038/s41598-017-02364-1. - DOI - PMC - PubMed
    1. Yokoi D., Atsuta N., Watanabe H., Nakamura R., Hirakawa A., Ito M., Watanabe H., Katsuno M., Izumi Y., Morita M., et al. Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis. J. Neurol. 2016;263:1129–1136. doi: 10.1007/s00415-016-8109-0. - DOI - PubMed
    1. Al-Chalabi A., Hardiman O. The epidemiology of ALS: A conspiracy of genes, environment and time. Nat. Rev. Neurol. 2013;9:617–628. doi: 10.1038/nrneurol.2013.203. - DOI - PubMed