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. 2020 Aug 5;12(8):2344.
doi: 10.3390/nu12082344.

Association of Serum Calcium and Phosphate Concentrations with Glucose Metabolism Markers: The Furukawa Nutrition and Health Study

Shamima Akter  1 , Masafumi Eguchi  2 , Takeshi Kochi  2 , Isamu Kabe  2 , Akiko Nanri  1   3 , Tetsuya Mizoue  1
Affiliations

Association of Serum Calcium and Phosphate Concentrations with Glucose Metabolism Markers: The Furukawa Nutrition and Health Study

Shamima Akter et al. Nutrients. .

Abstract

Calcium and phosphate may play an important role in cardio-metabolic abnormalities, including type 2 diabetes; however, epidemiological evidence of the association of calcium and phosphate status with glucose metabolism among Asians is limited. In the current study, we performed a cross-sectional analysis of the association of serum calcium, phosphate, and calcium-phosphate product concentrations with glucose metabolism markers among Japanese individuals. Overall, 1701 workers (aged 18-78 years) who participated in a health survey were enrolled in this study. Multivariable linear regression models were used to estimate means of homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β), and glycated hemoglobin (HbA1c). Serum calcium concentration was positively associated with HOMA-IR and HbA1c (p for trend < 0.01). Multivariable-adjusted means (95% confidence interval (CI)) of HOMA-IR for the lowest and highest quartiles of serum calcium were 0.78 (0.75-0.82) and 1.01 (0.96-1.07), respectively. The corresponding values for HbA1c were 5.24 (5.22-5.27) and 5.29 (5.26-5.32), respectively. Serum phosphate and calcium-phosphate product concentrations were inversely associated with HOMA-IR (p for trend < 0.01). Multivariable-adjusted means (95% CI) of HOMA-IR for the lowest and highest quartiles of serum phosphate were 1.04 (0.99-1.09) and 0.72 (0.69-0.76), respectively. The corresponding values for calcium-phosphate product were 1.04 (0.99-1.09) and 0.73 (0.69-0.77), respectively. The current findings suggest that higher serum calcium and lower serum phosphate concentrations are associated with IR among apparently healthy adults.

Keywords: calcium–phosphate product; insulin resistance; serum calcium; serum phosphate.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study population.
See this image and copyright information in PMC

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