Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug 5;21(16):5619.
doi: 10.3390/ijms21165619.

Multidrug-Resistant Gram-Negative Bacteria Decolonization in Immunocompromised Patients: A Focus on Fecal Microbiota Transplantation

Laura Alagna  1 , Emanuele Palomba  1   2   3 , Davide Mangioni  1   4 , Giorgio Bozzi  1 , Andrea Lombardi  1 , Riccardo Ungaro  1 , Valeria Castelli  1   2   3 , Daniele Prati  5 , Maurizio Vecchi  2   6 , Antonio Muscatello  1 , Alessandra Bandera  1   2   3 , Andrea Gori  1   2   3
Affiliations
Review

Multidrug-Resistant Gram-Negative Bacteria Decolonization in Immunocompromised Patients: A Focus on Fecal Microbiota Transplantation

Laura Alagna et al. Int J Mol Sci. .

Abstract

Antimicrobial resistance is an important issue for global health; in immunocompromised patients, such as solid organ and hematological transplant recipients, it poses an even bigger threat. Colonization by multidrug-resistant (MDR) bacteria was acknowledged as a strong risk factor to subsequent infections, especially in individuals with a compromised immune system. A growing pile of studies has linked the imbalance caused by the dominance of certain taxa populating the gut, also known as intestinal microbiota dysbiosis, to an increased risk of MDR bacteria colonization. Several attempts were proposed to modulate the gut microbiota. Particularly, fecal microbiota transplantation (FMT) was successfully applied to treat conditions like Clostridioides difficile infection and other diseases linked to gut microbiota dysbiosis. In this review we aimed to provide a look at the data gathered so far on FMT, focusing on its possible role in treating MDR colonization in the setting of immunocompromised patients and analyzing its efficacy and safety.

Keywords: antimicrobial resistance; decolonization; dysbiosis; fecal microbiota transplantation; gut colonization; gut microbiota; immunocompromised; multidrug-resistant.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Cassini A., Högberg L.D., Plachouras D., Quattrocchi A., Hoxha A., Simonsen G.S., Colomb-Cotinat M., Kretzschmar M.E., Devleesschauwer B., Cecchini M., et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis. Lancet Infect. Dis. 2018;19:56–66. doi: 10.1016/S1473-3099(18)30605-4. - DOI - PMC - PubMed
    1. Magiorakos A.-P., Srinivasan A., Carey R., Carmeli Y., Falagas M.E., Giske C., Harbarth S., Hindler J., Kahlmeter G., Olsson-Liljequist B., et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol. Infect. 2012;18:268–281. doi: 10.1111/j.1469-0691.2011.03570.x. - DOI - PubMed
    1. European Centre for Disease Prevention and Control . Surveillance of Antimicrobial Resistance in Europe. ECDC; Stockholm, Sweden: 2018. 2019.
    1. European Centre for Disease Prevention and Control . Carbapenem-Resistant Enterobacteriaceae Second Update. ECDC; Stockholm, Sweden: 2019. 26 September 2019.
    1. Costello E.K., Lauber C.L., Hamady M., Fierer N., Gordon J.I., Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326:1694–1697. doi: 10.1126/science.1177486. - DOI - PMC - PubMed

MeSH terms