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Review
. 2020 Aug;27(8):687-695.
doi: 10.1038/s41594-020-0474-9. Epub 2020 Aug 6.

Safeguarding mitochondrial genomes in higher eukaryotes

Yi Fu  1 , Marco Tigano  1 , Agnel Sfeir  2
Affiliations
Review

Safeguarding mitochondrial genomes in higher eukaryotes

Yi Fu et al. Nat Struct Mol Biol. 2020 Aug.

Abstract

Mitochondria respond to DNA damage and preserve their own genetic material in a manner distinct from that of the nucleus but that requires organized mito-nuclear communication. Failure to resolve mtDNA breaks leads to mitochondrial dysfunction and affects host cells and tissues. Here, we review the pathways that safeguard mitochondrial genomes and examine the insights gained from studies of cellular and tissue-wide responses to mtDNA damage and mito-nuclear genome incompatibility.

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References

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