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Review
. 2020 Jul 23;11(4):967-977.
doi: 10.14336/AD.2019.0901. eCollection 2020 Jul.

Targeting AMP-Activated Protein Kinase in Aging-Related Cardiovascular Diseases

Tian Li  1 , Nan Mu  1 , Yue Yin  1 , Lu Yu  2 , Heng Ma  1
Affiliations
Review

Targeting AMP-Activated Protein Kinase in Aging-Related Cardiovascular Diseases

Tian Li et al. Aging Dis. .

Abstract

Aging is a pivotal risk factor for developing cardiovascular diseases (CVD) due to the lifelong exposure to various risk factors that may affect the heart and vasculature during aging. AMP-activated protein kinase (AMPK), a serine/threonine protein kinase, is a pivotal endogenous energy regulator that protects against various pathological alterations. In this report, we first introduced the protective mechanisms of AMPK signaling in myocardium, such as oxidative stress, apoptosis, inflammation, autophagy and inflammatory response. Next, we introduced the potential correlation between AMPK and cardiac aging. Then, we highlighted the roles of AMPK signaling in cardiovascular diseases, including myocardial ischemia, cardiomyopathy, and heart failure. Lastly, some potential directions and further perspectives were expanded. The information extends our understanding on the protective roles of AMPK in myocardial aging, which may contribute to the design of drug targets and sheds light on potential treatments of AMPK for aging-related CVD.

Keywords: AMPK; Aging; Cardioprotecion; Cardiovascular diseases.

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Conflict of interest statement

Conflict of interest statement The authors have no conflict of interests to declare.

References

    1. Alfaras I, Di Germanio C, Bernier M, Csiszar A, Ungvari Z, Lakatta EG, et al. (2016). Pharmacological Strategies to Retard Cardiovascular Aging. Circ Res, 118:1626-1642. - PMC - PubMed
    1. Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. (2019). Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation, 139:e56-e528. - PubMed
    1. Bittner VA (2019). The New 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. Circulation. - PubMed
    1. Turdi S, Fan X, Li J, Zhao J, Huff AF, Du M, et al. (2010). AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell, 9:592-606. - PMC - PubMed
    1. McClellan M, Brown N, Califf RM, Warner JJ (2019). Call to Action: Urgent Challenges in Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation, 139:e44-e54. - PubMed

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