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. 2020 Jun 25;2(7):e0166.
doi: 10.1097/CCE.0000000000000166. eCollection 2020 Jul.

Factors Associated With Pulmonary Embolism Among Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: A Multicenter Study Among 375 Patients

Thibaud Soumagne  1 , Jean-Baptiste Lascarrou  2 , Sami Hraiech  3 , Geoffroy Horlait  4 , Julien Higny  5 , Alain d'Hondt  6 , David Grimaldi  7 , Stéphane Gaudry  8 , Romain Courcelle  9 , Giuseppe Carbutti  10 , Gauthier Blonz  11 , Nadia Aissaoui  12 , Christophe Vinsonneau  13 , Benoit Vandenbunder  14 , Julien Textoris  15 , Piotr Szychowiak  16 , Nicolas Serck  17 , Bertrand Sauneuf  18 , Michael Piagnerelli  19 , Andre Ly  20 , François Lejeune  21 , Laurent Lefebvre  22 , Gaël Piton  1
Affiliations

Factors Associated With Pulmonary Embolism Among Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: A Multicenter Study Among 375 Patients

Thibaud Soumagne et al. Crit Care Explor. .

Abstract

Risk factors associated with pulmonary embolism in coronavirus disease 2019 acute respiratory distress syndrome patients deserve to be better known. We therefore performed a post hoc analysis from the COronaVirus-Associated DIsease Study (COVADIS) project, a multicenter observational study gathering 21 ICUs from France (n = 12) and Belgium (n = 9). Three-hundred seventy-five consecutive patients with moderate-to-severe acute respiratory distress syndrome and positive coronavirus disease 2019 were included in the study. At day 28, 15% were diagnosed with pulmonary embolism. Known risk factors for pulmonary embolism including cancer, obesity, diabetes, hypertension, and coronary artery disease were not associated with pulmonary embolism. In the multivariate analysis, younger age (< 65 yr) (odds ratio, 2.14; 1.17-4.03), time between onset of symptoms and antiviral administration greater than or equal to 7 days (odds ratio, 2.39; 1.27-4.73), and use of neuromuscular blockers greater than or equal to 7 days (odds ratio, 1.89; 1.05-3.43) were independently associated with pulmonary embolism. These new findings reinforce the need for prospective studies that will determine the predictors of pulmonary embolism among patients with severe coronavirus disease 2019.

Keywords: acute respiratory distress syndrome; coronavirus disease 2019; critically ill; pulmonary embolism; severe acute respiratory syndrome coronavirus 2; thrombotic complications.

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Conflict of interest statement

Dr. Textoris is a part-time employee of bioMérieux, an IV diagnostics company, and Hospices Civils de Lyon, a university hospital. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1.
Figure 1.
Multivariate logistic regression analysis of factors associated with pulmonary embolism among patients with coronavirus disease 2019 acute respiratory distress syndrome. OR = odds ratio.
See this image and copyright information in PMC

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