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. 2021 Apr 3;10(3):363-366.
doi: 10.1093/jpids/piaa089.

Raltegravir-associated Drug-Reaction With Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient Without Characteristic Human Leukocyte Antigen B*57:01 or B*53:01 alleles

Sanya J Thomas  1 , Jacob T Kilgore  1 , Bradford A Becken  1 , Coleen K Cunningham  1   2 , Amelia B Thompson  1   3
Affiliations

Raltegravir-associated Drug-Reaction With Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient Without Characteristic Human Leukocyte Antigen B*57:01 or B*53:01 alleles

Sanya J Thomas et al. J Pediatric Infect Dis Soc. .

Abstract

We present the first published case of raltegravir-associated drug-reaction with eosinophilia and systemic symptoms (DRESS) syndrome in a child without characteristic human leukocyte antigen haplotypes HLA-B*57:01 or HLA-B*53:01. A 4-year-old African American female with perinatally acquired human immunodeficiency virus infection was hospitalized for DRESS after starting a raltegravir-based antiretroviral regimen.

Keywords: antiretroviral therapy; drug-reaction with eosinophilia and systemic symptoms syndrome; human immunodeficiency virus; human leukocyte antigen-B alleles; raltegravir.

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