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. 2020 Dec;27(35):44412-44426.
doi: 10.1007/s11356-020-10351-9. Epub 2020 Aug 7.

The protective efficacy of vitamin E and cod liver oil against cisplatin-induced acute kidney injury in rats

Azza M A Abo-Elmaaty  1 , Amany Behairy  2 , Nesma I El-Naseery  3 , Mohamed M Abdel-Daim  4   5
Affiliations

The protective efficacy of vitamin E and cod liver oil against cisplatin-induced acute kidney injury in rats

Azza M A Abo-Elmaaty et al. Environ Sci Pollut Res Int. 2020 Dec.

Abstract

Cisplatin (CP) is a highly effective chemotherapeutic agent against neoplasms, but its clinical utility is limited due to the side effects of its dose-dependent nephrotoxicity. Vitamin E (Vit E) and cod liver oil (CLO) are natural substances with chemoprotective effects. The present study was conducted to evaluate the protective effects of Vit E and/or CLO for CP-induced acute kidney injury (AKI) in rats. This study involved 40 mature male Wistar albino rats that were equally allocated into eight groups: Veh, Vit E, CLO, Vit E + CLO, CP, Vit E + CP, CLO + CP, and Vit E + CLO + CP. The co-administration of Vit E and CLO significantly ameliorated CP-induced elevations in serum creatinine (Cr), blood urea nitrogen (BUN), interleukin 1 beta (IL-1β), and interleukin- 6 (IL-6). Further, rats that received Vit E and/or CLO showed significant decrease in malondialdehyde (MDA) and increases in superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) levels in renal tissues, compared to CP-intoxicated rats. Additionally, the treatment restored the normal histological architecture (except for few cast formations) and upregulated the immunostaining area% of aquaporin 3 (AQP3) and downregulated the immunostaining area% of Bcl2 associated X protein (BAX) and inducible nitric oxide synthase (iNOS). The observed effects were stronger in the combination treatment group. The obtained data revealed that Vit E and CLO co-administration protects against the CP-induced AKI more than monotherapy with Vit E or CLO.

Keywords: Cisplatin; Cod liver oil; Immunohistochemical; Nephrotoxicity; Vitamin E.

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