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. 2020 Sep;56(9):1340-1342.
doi: 10.1111/jpc.15088. Epub 2020 Aug 7.

Elimination of typhoid: Possibility or pipe dream?

Rachael Purcell  1   2 , Andrew J Pollard  3   4
Affiliations

Elimination of typhoid: Possibility or pipe dream?

Rachael Purcell et al. J Paediatr Child Health. 2020 Sep.

Abstract

The elimination of typhoid would have a substantial impact on the health of millions of people living in South and Southeast Asia and sub-Saharan Africa. Like many diseases before it, there are significant challenges to elimination, including access to safe drinking water and adequate sanitation practices, the availability of a vaccine, the identification and management of chronic carriers and the emergence of anti-microbial resistance. While provision of clean water and adequate sanitation must remain the ultimate goal, in the short term, required to cornerstone elimination in endemic areas, is an efficacious vaccine. Recent evidence of effectiveness with a tetanus-toxoid conjugate vaccine offers an opportunity for an immunogenic and safe vaccine able to be delivered to young children. Shown to be efficacious in Nepal, where infection is endemic, it may be a viable option in public health programmes moving towards elimination.

Keywords: elimination; paratyphoid; tetanus-toxoid conjugated Vi polysaccharide vaccine; typhoid.

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References

    1. Harris JB, Brooks WA. Hunter's Tropical Medicine and Emerging Infectious Diseases, 9th edn. Philadelphia, PA: Elsevier; 2013.
    1. Bhutta ZA. Impact of age and drug resistance on mortality in typhoid fever. Arch. Dis. Child. 1996; 75: 214-7.
    1. GBD 2017 Typhoid and Paratyphoid Collaborators. The global burden of typhoid and paratyphoid fevers: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect. Dis. 2019; 19: P369-81.
    1. The SAGE Working Group on Typhoid Vaccines WS. Background Paper to SAGE on Typhoid Vaccine Policy Recommendations. Geneva: World Health Organization; 2017.
    1. Mohan VK, Varanasi V, Singh A et al. Safety and immunogenicity of a Vi polysaccharide-tetanus toxoid conjugate vaccine (Typbar-TCV) in healthy infants, children, and adults in typhoid endemic areas: A multicentre, 2-cohort, open-label, double-blind, randomized controlled phase 3 study. Clin. Infect. Dis. 2015; 61: 393-402.

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