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Comment
. 2020 Aug 25;117(34):20357-20359.
doi: 10.1073/pnas.2013380117. Epub 2020 Aug 7.

Reinventing the wheel with a synthetic plant inflammasome

Adam M Bayless  1 , Marc T Nishimura  2
Affiliations
Comment

Reinventing the wheel with a synthetic plant inflammasome

Adam M Bayless et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Animal and plant NLRs form oligomeric wheels. (Left) The animal inflammasome is initiated when a single NAIP molecule (tan) is activated by a pathogen ligand (orange). Activated NAIP nucleates the formation of a wheel from NLRC monomers. Induced proximity of NLRC N termini activates caspase-1 (not shown) to initiate pyroptosis. (Middle) Plant CC-NLRs (e.g., ZAR1, green) can be activated by pathogen modification of host proteins (orange). Conformational change of ZAR1 leads to the formation of a pentameric wheel with a pyramidal N terminus proposed to be a pore-forming needle. A structure for a TIR-NLR oligomeric wheel has not been determined, but may be similar to ZAR1. The TIR domain (green circle) oligomerization is required for NADase function and cell death/immunity. (Right) A hybrid TIR-NLRC4 receptor can respond appropriately to NAIP5 activated by pathogen ligands to activate TIR enzymatic function and cell death.
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