Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2020 Dec;43(12):1413-1420.
doi: 10.1038/s41440-020-0529-7. Epub 2020 Aug 7.

Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels

Tilakezi Tuersun #  1 , Qin Luo #  1 , Zhihua Zhang  1 , Guoliang Wang  1 , Delian Zhang  1 , Menghui Wang  1 , Ting Wu  1 , Keming Zhou  1 , Na Yue  1 , Nanfang Li  2
Affiliations
Comparative Study

Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels

Tilakezi Tuersun et al. Hypertens Res. 2020 Dec.

Abstract

Primary aldosteronism (PA) is associated with a higher prevalence of abdominal aortic calcification (AAC). Unilateral and bilateral PA are the most common subtypes of PA. However, no studies have addressed the difference in the prevalence of AAC between the two subtypes. In addition to aldosterone, parathyroid hormone (PTH), an important regulator of calcium metabolism, was also reported to be elevated in individuals with unilateral PA. Therefore, we hypothesized that the prevalence of AAC may be higher in individuals with unilateral PA, which may be related to the plasma aldosterone concentration (PAC) and PTH levels. We included 156 PA patients who underwent adrenal venous sampling and 156 with essential hypertension (EH) matched by age and sex. Of the former, 76 were diagnosed with unilateral PA, and 80 were diagnosed with bilateral PA. The aortic calcification index (ACI) presented the severity of AAC and was measured by adrenal computed tomography scan. Our results showed that compared with the EH group, the prevalence and severity of AAC were higher in PA patients (32.7 vs. 19.6%; 4.32 ± 3.61% vs. 2.53 ± 2.42%, respectively). In the PA subgroup analysis, unilateral PA was associated with a higher and more severe AAC than bilateral PA (40.7 vs. 25.0%; 5.12 ± 4.07% vs. 3.08 ± 2.34%, respectively). Moreover, PAC and PTH levels were higher in individuals with unilateral PA than in those with bilateral PA (P < 0.05). After risk adjustment, multivariate regression analysis revealed that PAC and PTH were positively-associated with AAC in patients with PA (P < 0.05). In conclusion, unilateral PA patients exhibited a higher prevalence of AAC and more severe AAC due to elevated PAC and PTH levels.

Keywords: Abdominal aortic calcification; Bilateral primary aldosteronism; Parathyroid hormone; Plasma aldosterone concentration.; Unilateral primary aldosteronism.

PubMed Disclaimer

References

    1. Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline[J]. J Clin Endocrinol Metab. 2008;93:3266–81. - DOI
    1. Nishikawa T, Omura M, Satoh F, Shibata H, Takahashi K, Tamura N, et al. The Task Force Committee on Primary Aldosteronism, the Japan Endocrine Society. Guidelines for the diagnosis and treatment of primary aldosteronism-the Japan Endocrine Society 2009[J]. Endocr J. 2011;58:711–21. - DOI
    1. Monticone S, D’Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F, et al. Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis[J]. Lancet Diabetes Endocrinol. 2018;6:41–50. - DOI
    1. Savard S, Amar L, Plouin PF, Steichen O. Cardiovascular complications associated with primary aldosteronism: a controlled cross-sectional study[J]. Hypertension. 2013;62:331–6. - DOI
    1. Mulatero P, Monticone S, Bertello C, Viola A, Tizzani D, Iannaccone A. et al. Long-term cardio-and cerebrovascular events in patients with primary aldosteronism[J]. J Clin Endocrinol Metab. 2013;98:4826–33. - DOI

Publication types

MeSH terms

LinkOut - more resources