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Comment
. 2020 Dec 18;22(12):1882-1883.
doi: 10.1093/neuonc/noaa186.

Letter regarding "Extensive brainstem infiltration, not mass effect, is a common feature of end-stage cerebral glioblastomas"

Jubayer A Hossain  1   2 , Hrvoje Miletic  1   2
Affiliations
Comment

Letter regarding "Extensive brainstem infiltration, not mass effect, is a common feature of end-stage cerebral glioblastomas"

Jubayer A Hossain et al. Neuro Oncol. .
No abstract available

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Figures

Fig. 1
Fig. 1
Tumor recurrence after suicide gene therapy. (A‒D) Hematoxylin and eosin (H&E) stainings of 4 recurrent and invasive tumors in the mesencephalon/pons. Arrows indicate virtual tumor borders. (E) H&E staining of a small tumor lesion with invasive tumor cells at the primary site (cerebrum) from one animal with the main tumor recurrence in the pons/mesencephalon. Arrows indicate virtual tumor border. (F) H&E staining of a primary tumor in the cerebrum of one control animal showing a typical GBM phenotype with palisading necrosis.
See this image and copyright information in PMC

Comment on

References

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    1. Talasila KM, Soentgerath A, Euskirchen P, et al. . EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol. 2013;125(5):683–698. - PMC - PubMed
    1. Lee J, Kotliarova S, Kotliarov Y, et al. . Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 2006;9(5):391–403. - PubMed