Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov 2;73(9):e3102-e3105.
doi: 10.1093/cid/ciaa1165.

Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Mathilde Bellon  1   2   3 , Cecilia Schweblin  1   2   3 , Nathalie Lambeng  4 , Pascal Cherpillod  1 , Jessica Vazquez  4 , Patrice H Lalive  3   5   6   7 , Manuel Schibler  1   2 , Christine Deffert  4   5
Affiliations

Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Mathilde Bellon et al. Clin Infect Dis. .

Abstract

This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.

Keywords: COVID-19; SARS-CoV-2; blood-brain barrier; intrathecal synthesis; neurological manifestations.

PubMed Disclaimer

Publication types

Substances