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Case Reports
. 2021 Apr;268(4):1191-1194.
doi: 10.1007/s00415-020-10133-w. Epub 2020 Aug 8.

SARS-CoV-2 associated Guillain-Barré syndrome

Teodor Pelea  1 , Ursula Reuter  1 , Christine Schmidt  1 , Raimondo Laubinger  2 , Robert Siegmund  3 , Bjoern Wito Walther  4
Affiliations
Case Reports

SARS-CoV-2 associated Guillain-Barré syndrome

Teodor Pelea et al. J Neurol. 2021 Apr.

Abstract

Presented herein is a severe case of SARS-CoV-2 associated Guillain-Barré syndrome (GBS), showing only slight improvement despite adequate therapy. To date, only few cases of GBS associated with this infection have been described. This case report summarizes the insights gain so far to GBS with this antecedent trigger. So far, attention has mostly focused on complications of the CNS involvement. Taking into account that GBS can cause a considerable impairment of the respiratory system, clinicians dealing with SARS-CoV-2 positive-tested patients should pay attention to symptoms of the peripheral nervous system. As far as we know from this reported case and the review of the current literature, there seems to be no association with antiganglioside antibodies or a positive SARS-CoV-2 RT-PCR in CSF. An obvious frequent occurrence of a bilateral facial weakness or bilateral peripheral facial diplegia should be emphasized.

Keywords: Bilateral facial diplegia; COVID-19; Guillain–Barré syndrome; SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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