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Case Reports
. 2020 Nov;37(6):1119-1124.
doi: 10.1111/pde.14324. Epub 2020 Aug 8.

Epidermal necrolysis as the presenting manifestation of pediatric lupus

Dharmagat Bhattarai  1 , Pandiarajan Vignesh  1 , Himanshi Chaudhary  1 , Niteesh Bharadwaj  1 , Lokesh Saini  1 , Kirti Gupta  2 , Amit Rawat  1
Affiliations
Case Reports

Epidermal necrolysis as the presenting manifestation of pediatric lupus

Dharmagat Bhattarai et al. Pediatr Dermatol. 2020 Nov.

Abstract

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represents the spectrum of skin lesions characterized by rashes, exfoliation, and sloughing usually following drug intake. Occasionally, TEN-like cutaneous manifestations have also been described with systemic lupus erythematosus. Recognition of lupus in a child presenting with TEN-like skin changes is clinically challenging and requires a high degree of suspicion. We describe the case of a child who had epidermal necrolysis as the presenting feature of lupus and had severe neurological complications. TEN-like skin changes in association with severe neurological complications in pediatric lupus are uncommon. Lupus must be considered in the differential diagnosis of a child presenting with epidermal necrolysis with no provocative risk factors such as a history of exposure to medications.

Keywords: TEN-like lupus; childhood lupus; systemic lupus erythematosus; toxic epidermal necrolysis.

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References

REFERENCES

    1. Li AW, Weed JG, Stamey CR, Subtil A, Tomayko MM, Antaya RJ. Bullous systemic lupus erythematosus in a 6-year-old boy. Pediatr Dermatol. 2017;34(6):e313-e316.
    1. Horne NS, Narayan AR, Young R-M, Frieri M. Toxic epidermal necrolysis in systemic lupus erythematosus. Autoimmun Rev. 2006;5(2):160-164.
    1. Camisa C, Sharma HM. Vesiculobullous systemic lupus erythematosus. Report of two cases and a review of the literature. J Am Acad Dermatol. 1983;9(6):924-933.
    1. Chan HL. Observations on drug-induced toxic epidermal necrolysis in Singapore. J Am Acad Dermatol. 1984;10(6):973-978.
    1. Auquier-Dunant A, Mockenhaupt M, Naldi L, et al. Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. Arch Dermatol. 2002;138(8):1019-1024.

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