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Meta-Analysis
. 2020 Sep-Oct;14(5):1463-1465.
doi: 10.1016/j.dsx.2020.07.054. Epub 2020 Aug 1.

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection

Affiliations
Meta-Analysis

Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection

Timotius Ivan Hariyanto et al. Diabetes Metab Syndr. 2020 Sep-Oct.

Abstract

Background and aims: The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing. The identification of risk factors for severe outcomes is important. Dyslipidemia has been shown as a long-known risk factor for cardiovascular disease. The aim of this study is to analyze the potential association between dyslipidemia and the severity of COVID-19 infection.

Methods: We systematically searched the PubMed database using specific keywords related to our aims until July 9th, 2020. All articles published on COVID-19 and dyslipidemia were retrieved. Statistical analysis was done using Review Manager 5.4 software.

Results: A total of 7 studies with a total of 6922 patients were included in our analysis. Our meta-analysis showed that dyslipidemia is associated with severe COVID-19 infections [RR 1.39 (95% CI 1.03-1.87), p = 0.03, I2 = 57%, random-effect modelling].

Conclusion: Dyslipidemia increases the risk of the development of severe outcomes from COVID-19 infections. Patients with dyslipidemia should be monitored closely to minimize the risk of COVID-19.

Keywords: COVID-19; Coronavirus disease 2019; Dyslipidemia; Metabolic disease; Metabolic syndrome.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest regarding this article.

Figures

Fig. 1
Fig. 1
Forest plot that demonstrates the association of dyslipidemia with severe COVID-19 disease.

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