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Case Reports
. 2021 Feb;23(1):e13441.
doi: 10.1111/tid.13441. Epub 2020 Aug 16.

Very late-onset cytomegalovirus disease with ganciclovir resistance >15 years following renal transplantation

Sadid F Khan  1 , Michelle K Yong  1   2   3   4 , Monica A Slavin  1   2   3   4 , Peter Hughes  5   6 , Joseph Sasadeusz  1   2
Affiliations
Case Reports

Very late-onset cytomegalovirus disease with ganciclovir resistance >15 years following renal transplantation

Sadid F Khan et al. Transpl Infect Dis. 2021 Feb.

Abstract

Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality after solid organ transplantation. There has been a significant shift in disease epidemiology with the introduction of antiviral prophylaxis, with CMV disease occurring later and clinical presentations more atypical. We describe two cases of very late-onset CMV disease where first disease occurred 15 and 18 years post-renal transplantation, with both cases complicated by antiviral drug resistance. We subsequently review the published cases and literature of very late-onset CMV disease (onset > 10 years post-solid organ transplantation) as an increasingly recognized phenomenon which is emerging as an important aspect in improving long-term patient outcomes in the current era of renal transplantation.

Keywords: antiviral drug resistance; cytomegalovirus; renal transplant.

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References

REFERENCES

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