International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

Tereza Martinu¹, Angela Koutsokera², Christian Benden³, Edward Cantu⁴, Daniel Chambers⁵, Marcelo Cypel⁶, Jeffrey Edelman⁷, Amir Emtiazjoo⁸, Andrew J Fisher⁹, John R Greenland¹⁰, Don Hayes Jr¹¹, David Hwang¹², Brian C Keller¹³, Erika D Lease¹⁴, Michael Perch¹⁵, Masaaki Sato¹⁶, Jamie L Todd¹⁷, Stijn Verleden¹⁸, Jan von der Thüsen¹⁹, S Samuel Weigt²⁰, Shaf Keshavjee⁶; bronchoalveolar lavage standardization workgroup

Collaborators, Affiliations

Collaborators

bronchoalveolar lavage standardization workgroup:
Tereza Martinu, Angela Koutsokera, Shaf Keshavjee, S Samuel Weigt, Masaaki Sato, Cecilia Chaparro, David Wilson Roe, Frank D'Ovidio, George Chaux, Greg Snell, Laurent Godinas, Mohamed Al-Aloul, Steven Hays, Jamie Todd, Michael Perch, Amy Rigby, Louis Clauden, Matthew Morrell, Puneet Garcha, Sanjeev Raman, Soma Jyothula, Michael Trotter, Erika Lease, Jeffrey Edelman, Cassie Kennedy, Chadi A Hage, Saima Aslam, Shahid Husain, Jan von der Thüsen, Andrew J Fisher, Katharina Wassilew, Reinaldo Rampolla-Selles, Siddhartha G Kapnadak, Umesh Goswami, John Greenland, Amir Emtiazjoo, Aric Gregson, Bart Vanaudenaerde, Tji Gan, David Hwang, Brian Keller, Laura K Frye, Margaret Hannan, Harish Seethamraju, Rade Tomic, Remzi Bag, Alicia Mitchell, Stijn Verleden, Daniel Chambers, Jorge Mallea, Maria Crespo, Sangeeta Bhorade, Cantu Edward, Cypel Marcelo, Gundeep Dhillon, Jason Christie, Jessica Gy Luc, Shaf Keshavjee, Keith M Wille, Olufemi Akindipe, Omar Mohamedaly, Christopher Wigfield, Don Hayes, Christian Benden, Ernestina Melicoff-Portillo, Marc Schecter, Shailendra Das, Ani Orchanian-Cheff, George Tomlinson

Affiliations

¹ Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: tereza.martinu@uhn.ca.
² Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Lung Transplant Program, Division of Pulmonology, Lausanne University Hospital, Lausanne, Switzerland.
³ University of Zurich Faculty of Medicine, Zurich, Switzerland.
⁴ Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
⁵ Lung Transplant Program, The Prince Charles Hospital, Brisbane, Queensland, Australia.
⁶ Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
⁷ Lung Transplant Program, Puget Sound VA Medical Center, Seattle, Washington.
⁸ Lung Transplant Program, University of Florida, Gainesville, Florida.
⁹ Institute of Transplantation, Newcastle Upon Tyne Hospitals and Newcastle University, United Kingdom.
¹⁰ Department of Medicine, VA Health Care System, San Francisco, California.
¹¹ Lung Transplant Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
¹² Department of Pathology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
¹³ Lung Transplant Program, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
¹⁴ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
¹⁵ Lung Transplant Program, Rigshospitalet, Copenhagen, Denmark.
¹⁶ Department of Surgery, University of Tokyo, Tokyo, Japan.
¹⁷ Lung Transplant Program, Duke University Medical Center, Durham, North Carolina.
¹⁸ Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium.
¹⁹ Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.
²⁰ Lung Transplant Program, University of California Los Angeles, Los Angeles, California.

PMID: 32773322
PMCID: PMC7361106
DOI: 10.1016/j.healun.2020.07.006

Editorial

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

Tereza Martinu et al. J Heart Lung Transplant. 2020 Nov.

. 2020 Nov;39(11):1171-1190.

doi: 10.1016/j.healun.2020.07.006. Epub 2020 Jul 15.

Authors

Collaborators

bronchoalveolar lavage standardization workgroup:
Tereza Martinu, Angela Koutsokera, Shaf Keshavjee, S Samuel Weigt, Masaaki Sato, Cecilia Chaparro, David Wilson Roe, Frank D'Ovidio, George Chaux, Greg Snell, Laurent Godinas, Mohamed Al-Aloul, Steven Hays, Jamie Todd, Michael Perch, Amy Rigby, Louis Clauden, Matthew Morrell, Puneet Garcha, Sanjeev Raman, Soma Jyothula, Michael Trotter, Erika Lease, Jeffrey Edelman, Cassie Kennedy, Chadi A Hage, Saima Aslam, Shahid Husain, Jan von der Thüsen, Andrew J Fisher, Katharina Wassilew, Reinaldo Rampolla-Selles, Siddhartha G Kapnadak, Umesh Goswami, John Greenland, Amir Emtiazjoo, Aric Gregson, Bart Vanaudenaerde, Tji Gan, David Hwang, Brian Keller, Laura K Frye, Margaret Hannan, Harish Seethamraju, Rade Tomic, Remzi Bag, Alicia Mitchell, Stijn Verleden, Daniel Chambers, Jorge Mallea, Maria Crespo, Sangeeta Bhorade, Cantu Edward, Cypel Marcelo, Gundeep Dhillon, Jason Christie, Jessica Gy Luc, Shaf Keshavjee, Keith M Wille, Olufemi Akindipe, Omar Mohamedaly, Christopher Wigfield, Don Hayes, Christian Benden, Ernestina Melicoff-Portillo, Marc Schecter, Shailendra Das, Ani Orchanian-Cheff, George Tomlinson

Affiliations

¹ Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: tereza.martinu@uhn.ca.
² Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Lung Transplant Program, Division of Pulmonology, Lausanne University Hospital, Lausanne, Switzerland.
³ University of Zurich Faculty of Medicine, Zurich, Switzerland.
⁴ Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
⁵ Lung Transplant Program, The Prince Charles Hospital, Brisbane, Queensland, Australia.
⁶ Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
⁷ Lung Transplant Program, Puget Sound VA Medical Center, Seattle, Washington.
⁸ Lung Transplant Program, University of Florida, Gainesville, Florida.
⁹ Institute of Transplantation, Newcastle Upon Tyne Hospitals and Newcastle University, United Kingdom.
¹⁰ Department of Medicine, VA Health Care System, San Francisco, California.
¹¹ Lung Transplant Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
¹² Department of Pathology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
¹³ Lung Transplant Program, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
¹⁴ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington.
¹⁵ Lung Transplant Program, Rigshospitalet, Copenhagen, Denmark.
¹⁶ Department of Surgery, University of Tokyo, Tokyo, Japan.
¹⁷ Lung Transplant Program, Duke University Medical Center, Durham, North Carolina.
¹⁸ Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium.
¹⁹ Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.
²⁰ Lung Transplant Program, University of California Los Angeles, Los Angeles, California.

PMID: 32773322
PMCID: PMC7361106
DOI: 10.1016/j.healun.2020.07.006

Abstract

Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation (LTx). However, BAL collection and processing are not standardized across LTx centers. This International Society for Heart and Lung Transplantation-supported consensus document on BAL standardization aims to clarify definitions and propose common approaches to improve clinical and research practice standards. The following 9 areas are covered: (1) bronchoscopy procedure and BAL collection, (2) sample handling, (3) sample processing for microbiology, (4) cytology, (5) research, (6) microbiome, (7) sample inventory/tracking, (8) donor bronchoscopy, and (9) pediatric considerations. This consensus document aims to harmonize clinical and research practices for BAL collection and processing in LTx. The overarching goal is to enhance standardization and multicenter collaboration within the international LTx community and enable improvement and development of new BAL-based diagnostics.

Keywords: bronchial wash; bronchoalveolar lavage; donor bronchoscopy; lung transplantation; methodology; pediatric bronchoscopy; standardization.

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References

1. Kennedy VE, Todd JL, Palmer SM. Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome. Am J Transplant. 2013;13:552–561. - PMC - PubMed
1. Speck NE, Schuurmans MM, Benden C, Robinson CA, Huber LC. Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers. Respir Res. 2017;18:151. - PMC - PubMed
1. Speck NE, Schuurmans MM, Murer C, Benden C, Huber LC. Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology. Respir Res. 2016;17:74. - PMC - PubMed
1. Greenland JR, Jewell NP, Gottschall M. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. Am J Transplant. 2014;14:831–840. - PMC - PubMed
1. Cantu E, Lederer DJ, Meyer K. Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation. Am J Transplant. 2013;13:1898–1904. - PMC - PubMed

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International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

Collaborators

Affiliations

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

Authors

Collaborators

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical