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Review
. 2020 Jul 22:2020:7259686.
doi: 10.1155/2020/7259686. eCollection 2020.

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

Jing-Xian Chen  1   2 , Chien-Shan Cheng  3   4 , Jie Chen  5 , Ling-Ling Lv  1 , Zi-Jie Chen  6 , Chuan Chen  7 , Lan Zheng  1   2
Affiliations
Review

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

Jing-Xian Chen et al. Evid Based Complement Alternat Med. .

Abstract

Cynanchum paniculatum Radix, known as Xuchangqing in Chinese, is commonly prescribed in Chinese Medicine (CM) for the treatment of various inflammatory diseases. The anti-inflammatory property of Cynanchum paniculatum can be traced from its wind-damp removing, collaterals' obstruction relieving, and toxins counteracting effects as folk medicine in CM. This paper systematically reviewed the research advancement of the pharmacological effects of Cynanchum paniculatum among a variety of human diseases, including diseases of the respiratory, circulatory, digestive, urogenital, hematopoietic, endocrine and metabolomic, neurological, skeletal, and rheumatological systems and malignant diseases. This review aims to link the long history of clinical applications of Cynanchum paniculatum in CM with recent biomedical investigations. The major bioactive chemical compositions of Cynanchum paniculatum and their associated action mechanism unveiled by biomedical investigations as well as the present clinical applications and future perspectives are discussed. The major focuses of this review are on the diverse mechanisms of Cynanchum paniculatum and the role of its active components in inflammatory diseases.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Dry herb of Cynanchum paniculatum and chemical composition of its major constituent: (a) dry herb of XCQ; (b) paeonol (C99H10O3, CAS number 552-41-0); (c) antofine (C23H25NO3, CAS number 32671-82-2); (d) cynanversicoside A (C42H64O15, CAS number 138875-31-7); (e) cynanversicoside C (C28H40O10, CAS number 934701-03-8); (f) 3-hydroxy-4-methoxy-acetophenone (C9H10O3, CAS number 6100-74-9).
Figure 2
Figure 2
The number of publications by year showed an increase of research attention on Cynanchum paniculatum and its major constituents in recent years across the Chinese and English literature.
Figure 3
Figure 3
Schematic diagram of the anti-inflammatory pharmacological effects of Cynanchum paniculatum.
Figure 4
Figure 4
Role of Cynanchum paniculatum chronic inflammation related human diseases.
See this image and copyright information in PMC

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