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Review
. 2020 Jul 28:2020:6329321.
doi: 10.1155/2020/6329321. eCollection 2020.

The Prevalence of Infectious Keratitis after Keratorefractive Surgery: A Systematic Review and Meta-Analysis Study

Shahla Afsharpaiman  1 , Musa Zare  2 , Masoud Yasemi  1 , Tannaz Jamialahmadi  3   4 , Amirhossein Sahebkar  5   6   7
Affiliations
Review

The Prevalence of Infectious Keratitis after Keratorefractive Surgery: A Systematic Review and Meta-Analysis Study

Shahla Afsharpaiman et al. J Ophthalmol. .

Abstract

Background: The keratorefractive surgeries (KRS) are one of the most common ocular surgeries. One of the dangerous complications of these surgeries is infectious keratitis (IK), which is the second cause of blindness after cataract surgery. The purpose of this study was to estimate the prevalence of IK after KRS in different parts of the world.

Methods: In order to obtain relevant studies, all national and international databases including IranMedex, SID, Magiran, IranDoc, Medlib, ScienceDirect, PubMed, Scopus, Cochrane, Embase, Web of Science, and Google Scholar were searched using standard keywords.

Results: IK prevalence after KRS was 0.000496% (0.000145% for the left eye and 0.000149% for the right eye). IK prevalence after KRS in the United States, Europe, and Asia was 0.000667%, 0.000473%, and 0.000045%, respectively, in all of which the common microorganisms were Staphylococci. Meta-regression showed no significant association between IK after KRS and either sample size or publication year of the studies. IK prevalence after KRS in the right eye was more than that in the left one. Also, the probability of IK incidence after LASIK surgery was more than PRK and LASEK. In the evaluation of continents, IK after KRS in the United States was more frequent compared with Europe and Asia.

Conclusions: This study provided data as to the overall prevalence of IK following KRS and its variations according to the types of eye, surgery, pathogenic microorganism, and geographical location.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the evaluated studies into meta-analysis.
Figure 2
Figure 2
The incidence of infectious keratitis after performing the keratorefractive surgery, according to the author's name and the year of research, based on the random effects model. The midpoint of each line segment reveals the incidence of infectious keratitis after conducting the keratorefractive surgery for each study. The rhombus form also shows the incidence of infectious keratitis after performing the keratorefractive surgery for all studies.
Figure 3
Figure 3
Relationship between the prevalence of infectious keratitis after performing the keratorefractive surgery with the year of publication of the article by using the meta-regression model.
Figure 4
Figure 4
Relationship between the incidence of infectious keratitis and the number of research samples after keratorefractive surgery.
See this image and copyright information in PMC

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