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Case Reports
. 2020 Jul 24:2020:7514051.
doi: 10.1155/2020/7514051. eCollection 2020.

Spontaneous Gastric Necrosis: A Rare Presentation of Invasive Mucormycosis in an Immunocompetent Adult

Affiliations
Case Reports

Spontaneous Gastric Necrosis: A Rare Presentation of Invasive Mucormycosis in an Immunocompetent Adult

Tariq Hameed et al. Case Rep Infect Dis. .

Abstract

Spontaneous gastric perforations are usually seen in patients with untreated peptic ulcer disease. Mucormycosis, an uncommon, opportunistic, life-threatening fungal infection, rarely causes gastric perforation in immunocompetent adults. Here, we present a case of young female who was admitted to hospital for acute pain abdomen and distension with 5 days history of fever. She was operated and was found to have multiple perforations in the stomach with transmural necrosis. Despite adequate surgical excision and intravenous amphotericin B, patient succumbed to sequelae of infection.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
X-ray abdomen showing free gas under right dome of diaphragm.
Figure 2
Figure 2
The macroscopic appearance of the transmural gastric necrosis.
Figure 3
Figure 3
Photomicrograph of the histological appearance of mucormycosis. A gastric wall tissue section examined by light microscopy. The histology of the fungal form of mucormycosis shows large, nonseptate hyphae with 90 degree angle hyphal branching.
Figure 4
Figure 4
Photomicrographs showing the morphology of mucormycosis. Grocott-Gömöri methenamine silver stain (GMS) (black).

References

    1. Termos S., Othman F., Alali M., et al. Total gastric necrosis due to mucormycosis: a rare case of gastric perforation. American Journal of Case Reports. 2018;19:527–533. doi: 10.12659/ajcr.908952. - DOI - PMC - PubMed
    1. Chow V., Khan S., Balogun A., Mitchell D., Mühlschlegel F. A. Invasive rhino-orbito-cerebral mucormycosis in a diabetic patient-the need for prompt treatment. Medical Mycology Case Reports. 2015;8:5–9. doi: 10.1016/j.mmcr.2014.12.002. - DOI - PMC - PubMed
    1. Neofytos D., Horn D., Anaissie E., et al. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of multicenter prospective antifungal therapy (PATH) Alliance registry. Clinical Infectious Diseases. 2009;48(3):265–273. doi: 10.1086/595846. - DOI - PubMed
    1. Joshi N., Caputo G. M., Weitekamp M. R., Karchmer A. W. Infections in patients with diabetes mellitus. New England Journal of Medicine. 1999;341(25):1906–1912. doi: 10.1056/nejm199912163412507. - DOI - PubMed
    1. Chayakulkeeree M., Ghannoum M. A., Perfect J. R. Zygomycosis: the re-emerging fungal infection. European Journal of Clinical Microbiology & Infectious Diseases. 2006;25(4):215–229. doi: 10.1007/s10096-006-0107-1. - DOI - PubMed

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