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Case Reports
. 1988 Feb;108(2):204-6.
doi: 10.7326/0003-4819-108-2-204.

Lipids and lipoprotein changes after heart and liver transplantation in a patient with homozygous familial hypercholesterolemia

P Valdivielso  1 , J L Escolar, V Cuervas-Mons, L A Pulpón, M A Chaparro, P González-Santos
Affiliations
Case Reports

Lipids and lipoprotein changes after heart and liver transplantation in a patient with homozygous familial hypercholesterolemia

P Valdivielso et al. Ann Intern Med. 1988 Feb.

Abstract

Changes in lipids and lipoprotein fractions were studied 6 months after a combined heart and liver transplantation in a patient with terminal ischemic heart disease due to homozygous familial hypercholesterolemia. The double transplant was followed by striking decreases in total and low-density-lipoprotein cholesterol levels (-71% and -79%) and content of apolipoprotein B in the low-density-lipoprotein fraction (-74%). There was also an increase in high-density-lipoprotein cholesterol (+7.8%). These changes are greater than those reported with portacaval shunt or plasma exchange. Liver transplantation may be considered in selected patients with homozygous familial hypercholesterolemia.

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