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. 1988 Feb 1;260(2):622-7.
doi: 10.1016/0003-9861(88)90490-0.

Purification to homogeneity and some properties of squalene synthetase

K Sasiak  1 , H C Rilling
Affiliations

Purification to homogeneity and some properties of squalene synthetase

K Sasiak et al. Arch Biochem Biophys. .

Abstract

Squalene synthetase has been purified to homogeneity from yeast. It is a single polypeptide of Mr 47,000. This enzyme catalyzes the synthesis of squalene from farnesyl diphosphate via presqualene diphosphate. In the presence of reduced pyridine nucleotides, presqualene diphosphate and squalene are produced in a ratio of 6:1 from either the purified protein or the crude microsomal fraction.

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