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. 2020 Aug 3;7(6):713-715.
doi: 10.1002/mdc3.13019. eCollection 2020 Aug.

CRMP-5-IgG Associated Paraneoplastic Chorea

Pavan A Vaswani  1 , Eyal Y Kimchi  1 , Albert Y Hung  1
Affiliations

CRMP-5-IgG Associated Paraneoplastic Chorea

Pavan A Vaswani et al. Mov Disord Clin Pract. .
No abstract available

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Figures

Figure 1
Figure 1
Axial brain MRI demonstrated (A) extensive T2 hyperintense signal (arrows) with mild mass effect affecting the bilateral caudate nuclei and putamina (B) without associated restricted diffusion on diffusion‐weighted sequences and (C) without enhancement on T1 post‐gadolinium sequences. (D) Axial chest CT (greyscale) with superimposed [F18] FDG PET (color) demonstrated avid mediastinal and hilar lymphadenopathy (arrows) (E) biopsy demonstrated small blue cells with sparse cytoplasm without distinct nucleoli on H&E, positive for keratin, TTF1, synaptophysin, and chromogranin (patchy), consistent with small cell carcinoma.
See this image and copyright information in PMC

References

    1. Yu Z, Kryzer TJ, Griesmann GE, Kim K, Benarroch EE, Lennon VA. CRMP‐5 Neuronal Autoantibody: Marker of Lung Cancer and Thymoma‐Related Autoimmunity; 2001:146–154. 10.1002/1531-8249(20010201)49:2<146::AID-ANA34=3.0.CO;2-E. - DOI - PubMed
    1. Vigliani MC, Honnorat J, Antoine JC, et al. Chorea and related movement disorders of paraneoplastic origin: the PNS EuroNetwork experience. J Neurol 2011;258(11):2058–2068. 10.1007/s00415-011-6074-1 - DOI - PubMed
    1. Vernino S, Tuite P, Adler CH, et al. Paraneoplastic chorea associated with CRMP‐5 neuronal antibody and lung carcinoma. Ann Neurol 2002;51(5):625–630. 10.1002/ana.10178 - DOI - PubMed

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