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. 2020 Jul 26:32:106082.
doi: 10.1016/j.dib.2020.106082. eCollection 2020 Oct.

Dataset for homologous proteins in Drosophila melanogaster for SARS-CoV-2/human interactome

Mushtaq Hussain  1 , Nusrat Jabeen  2 , Sanya Shabbir  1   2 , Nasir Udin  3 , Basma Aziz  1 , Anusha Amanullah  1 , Fozia Raza  1 , Ayesha Ashraf Baig  1
Affiliations

Dataset for homologous proteins in Drosophila melanogaster for SARS-CoV-2/human interactome

Mushtaq Hussain et al. Data Brief. .

Abstract

Animal modelling for infectious diseases is critical to understand the biology of the pathogens including viruses and to develop therapeutic strategies against it. Herein, we present the sequence homology and expression data analysis of proteins found in Drosophila melanogaster that are orthologous to human proteins, reported as components of SARS-CoV-2/Human interactome. The dataset enlists sequence homology, query coverage, domain conservation, OrthoMCL and Ensembl Genome Browser support of 326 proteins in D.melanogaster that are potentially orthologous to 417 human proteins reported for their direct physical interactions with 28 proteins encoded by SARS-CoV-2 genome. Expression of these D.melanogaster orthologous genes in 26 anatomical positions are also plotted as heat maps in 27 sets, corresponding to the potential protein interactors for each viral protein. The data could be used to direct experiments and potentially predict their phenotypic and molecular outcome in order to dissect the biological roles and molecular functionality of SARS-CoV-2 proteins in a convenient animal model system like D.melanogaster.

Keywords: Animal modelling; COVID-19; Drosophila melanogaster; Interactome; SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships which have, or could be perceived to have, influenced the work reported in this article.

Figures

Fig 1
Fig. 1
Simplified molecular interaction network between SARS-CoV-2 proteins (blue diamonds) and human proteins (green circle).
Fig 2
Fig. 2
Schematic and scaled representation of SARS-CoV-2 genome with human protein interactors are indicated in the blocks linking respective viral proteins. Presence or absence of D.melanogaster orthologues of human proteins are mentioned by name or red cross, respectively.
Fig 3
Fig. 3
Heat maps showing the expression of D.melanogaster genes, orthologous to human proteins interactors with SARS-CoV-2 proteins as labelled on the top of each map.
See this image and copyright information in PMC

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