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Case Reports
. 2020 Jul 2;5(8):1350-1355.
doi: 10.1016/j.ekir.2020.06.016. eCollection 2020 Aug.

Drug-Induced Thrombotic Microangiopathy Resulting in ESRD

Krishna A Agarwal  1 , Yael K Heher  2 , Bradley M Denker  1
Affiliations
Case Reports

Drug-Induced Thrombotic Microangiopathy Resulting in ESRD

Krishna A Agarwal et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Peripheral blood smear. The yellow arrow is pointing at a normal-appearing red blood cell and blue arrows point at schistocytes.
Figure 2
Figure 2
Renal biopsy. (a) Arterioles contain fibrin thrombi (arrows) and intramural fragmented red blood cells or schistocytes (arrow heads). Tubular injury is seen diffusely. Masson trichrome stain, original magnification ×200. (b) Glomeruli contain fibrin thrombi (arrowheads) and show mesangiolysis (green arrow). The glomerular basement membrane shows diffuse ischemic changes. An arteriole contains an intraluminal fibrin thrombus (red arrow). Jones silver stain, original magnification ×200. (c) Arterioles and glomeruli contain abundant fibrin thrombi (red arrows). Direct immunofluorescence antifibrin, original magnification ×200. (d) Glomerular basement membranes show marked subendothelial lucency and flocculent material (asterisks), consistent with endothelial injury/thrombotic microangiopathy pattern. Electron microscopy, original magnification ×10,000.
See this image and copyright information in PMC

References

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