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. 2020 Aug;48(8):300060520934633.
doi: 10.1177/0300060520934633.

Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy

Liqin Zhang  1 , Lihua Zhang  2 , Zhangwei Wang  3 , Lingling Zhu  4 , Hongxing Wang  5 , Honghui Chen  4 , Haibo Zhang  6
Affiliations

Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy

Liqin Zhang et al. J Int Med Res. 2020 Aug.

Abstract

Objective: This study aimed to investigate application of the urine albumin-to-creatinine ratio (ACR), serum beta 2-microglobulin (β2-MG), and cystatin C as risk markers in a cohort of women with polycystic ovary syndrome (PCOS) for the incidence of gestational diabetes mellitus (GDM).

Methods: In this cross-sectional study, we analyzed 312 pregnant women with PCOS and classified them as those with and without GDM. For all participants, elbow venous blood and clean middle urine were collected in the morning after 8 hours of an empty stomach.

Results: Logistic regression analysis showed that the ACR, urine β2-MG levels, and serum cystatin C levels were important markers for women with PCOS concomitant with GDM. Receiver operating characteristic curve analysis showed that the area under the curve of CysC was 0.81 with the threshold based on >0.93 and that of β2-MG was 0.72 with the threshold based on >1.25.

Conclusions: Increased levels of β2-MG and cystatin C and a high ACR might be risk factors for Chinese women with PCOS and GDM during mid-pregnancy.

Keywords: Polycystic ovary syndrome; beta 2-microglobulin; cystatin C; gestational diabetes mellitus; risk marker; urine albumin-to-creatinine ratio.

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Figures

Figure 1.
Figure 1.
Receiver operating characteristic curve analysis of the predictive probabilities of ACR/β2-MG/CysC for gestational diabetes mellitus in women with polycystic ovary syndrome. ACR, albumin-to-creatinine ratio; β2-MG, beta 2-microglobulin; CysC, cystatin C.
See this image and copyright information in PMC

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References

    1. Legro RS, Arslanian SA, Ehrmann DA, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2013; 98: 4565–4592. - PMC - PubMed
    1. Ashrafi M, Sheikhan F, Arabipoor A, et al. Gestational diabetes mellitus risk factors in women with polycystic ovary syndrome (PCOS). Eur J Obstet Gynecol Reprod Biol 2014; 181: 195–199. - PubMed
    1. Mustaniemi S, Vaarasmaki M, Eriksson JG, et al. Polycystic ovary syndrome and risk factors for gestational diabetes. Endocr Connect 2018; 7: 859–869. - PMC - PubMed
    1. Song Y, Ye W, Ye H, et al. Serum testosterone acts as a prognostic indicator in polycystic ovary syndrome-associated kidney injury. Physiol Rep 2019; 7: e14219. - PMC - PubMed
    1. Beharier O, Shoham-Vardi I, Pariente G, et al. Gestational diabetes mellitus is a significant risk factor for long-term maternal renal disease. J Clin Endocrinol Metab 2015; 100: 1412–1416. - PubMed