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. 2020 Aug;48(8):300060520934633.
doi: 10.1177/0300060520934633.

Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy

Liqin Zhang  1 , Lihua Zhang  2 , Zhangwei Wang  3 , Lingling Zhu  4 , Hongxing Wang  5 , Honghui Chen  4 , Haibo Zhang  6
Affiliations

Increased risk markers in women with polycystic ovary syndrome and gestational diabetes mellitus during mid-pregnancy

Liqin Zhang et al. J Int Med Res. 2020 Aug.

Abstract

Objective: This study aimed to investigate application of the urine albumin-to-creatinine ratio (ACR), serum beta 2-microglobulin (β2-MG), and cystatin C as risk markers in a cohort of women with polycystic ovary syndrome (PCOS) for the incidence of gestational diabetes mellitus (GDM).

Methods: In this cross-sectional study, we analyzed 312 pregnant women with PCOS and classified them as those with and without GDM. For all participants, elbow venous blood and clean middle urine were collected in the morning after 8 hours of an empty stomach.

Results: Logistic regression analysis showed that the ACR, urine β2-MG levels, and serum cystatin C levels were important markers for women with PCOS concomitant with GDM. Receiver operating characteristic curve analysis showed that the area under the curve of CysC was 0.81 with the threshold based on >0.93 and that of β2-MG was 0.72 with the threshold based on >1.25.

Conclusions: Increased levels of β2-MG and cystatin C and a high ACR might be risk factors for Chinese women with PCOS and GDM during mid-pregnancy.

Keywords: Polycystic ovary syndrome; beta 2-microglobulin; cystatin C; gestational diabetes mellitus; risk marker; urine albumin-to-creatinine ratio.

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Figures

Figure 1.
Figure 1.
Receiver operating characteristic curve analysis of the predictive probabilities of ACR/β2-MG/CysC for gestational diabetes mellitus in women with polycystic ovary syndrome. ACR, albumin-to-creatinine ratio; β2-MG, beta 2-microglobulin; CysC, cystatin C.
See this image and copyright information in PMC

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