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. 2020 Aug 26;50(5):1307-1313.
doi: 10.3906/sag-2006-60.

Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid aortic valve degeneration

Bilge Duran Karaduman  1 , Hüseyin Ayhan  1 , Telat Keleş  2 , Engİn Bozkurt  3
Affiliations

Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid aortic valve degeneration

Bilge Duran Karaduman et al. Turk J Med Sci. .

Abstract

Background/aim: From a pathophysiological point of view, inflammation is thought to be more dominant in bicuspid aortic valve (BAV) stenosis than tricuspid aortic valve (TAV) stenosis. Our study aimed to determine the association between monocyte to high- density lipoprotein cholesterol (HDL-C) ratio (MHR), a new inflammatory marker, and the speed of progression of stenosis and pathophysiology of BAV stenosis.

Materials and methods: A total of 210 severe aortic stenosis patients (70 consecutive BAV patients, 140 matched TAV patients) were retrospectively enrolled in the study. Clinical and echocardiographic data and laboratory results related to our research were collected retrospectively from the patients’ records. MHR was measured as the ratio of the absolute monocyte count to the HDL-C value.

Results: Seventy BAV (mean age: 72.0 ± 9.1 years, 42.9% female) and 140 TAV patients (mean age: 77.9 ± 8.3 years, 51.4% female) with severe aortic stenosis were enrolled in this study. There was no difference between the two groups in terms of another baseline demographic or clinic findings except age (P < 0.001). Monocyte count, hemoglobin level, mean platelet volume was significantly higher, and HDL-C level was significantly lower in the BAV group, while other lipid and CBC parameters were found to be similar. In the multivariate analysis, MHR (P = 0.005, 95% CI: 0.90–0.98) and, as expected, age (P = 0.001, 95% CI: 1.02–1.11) were found to be significant as the independent predictor of BAV, after adjusting for other risk factors.

Conclusion: Our study showed a significant correlation between increased MHR and BAV. MHR was determined as a significant independent predictor for the speed of progression and diagnosis of severe BAV stenosis in multivariate analysis.

Keywords: Bicuspid aortic valve; aortic stenosis; inflammation; monocyte to high-density lipoprotein cholesterol ratio; tricuspid aortic valve.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

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References

    1. Benjamin EJ Muntner P Alonso A Bittencourt MS Callaway CW American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2019 Update: A report from the American Heart Association. Circulation . 2019;139:e56–e528. - PubMed
    1. Michelena HI Prakash SK Della Corte A Bissell MM Anavekar N Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon) BAVCon Investigators . 2014;129:2691–2704. - PMC - PubMed
    1. Corte Della Body A Booher SC Schaefers AM Milewski HJ Bicuspid Aortic Valve Consortium (BAVCon) Investigators RK Surgical treatment of bicuspid aortic valve disease: knowledge gaps and research perspectives. Journal of Thoracic and Cardiovascular Surgery . 2014;147:1749–1757. - PMC - PubMed
    1. Stewart BF Siscovick D Lind BK Gardin JM Gottdiener JS Clinical factors associated with calcific aortic valve disease Cardiovascular Health Study. Journal of the American College of Cardiology . 1997;29:630–634. - PubMed
    1. Dweck MR Boon NA Newby DE Calcific aortic stenosis: a disease of the valve and the myocardium. Journal of the American College of Cardiology . 2012;60:1854–1863. - PubMed

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